|
Acute myocardial infarction
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Compared with the SO group, Cx43, SOD, and Bcl-2 were decreased, MDA, Bax, caspase-3, TNF-α, IL-6, and HMGB1 were increased in the MI group, and all the alterations were significantly restrained in the LOMD+AMI group.
|
30516302 |
2019 |
|
Acute myocardial infarction
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
It was detected via RT-PCR and immunohistochemistry that, compared with those in the Sham group, the expression level of the anti-apoptosis gene B-cell lymphoma 2 (Bcl-2) was substantially decreased, but the expression levels of pro-apoptosis gene Bcl-2 associated X protein (Bax) and the JNK pathway-related JNK and c-Jun were evidently elevated in the AMI group (p<0.05).
|
31389586 |
2019 |
|
Acute myocardial infarction
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Preventive effect of hesperidin modulates inflammatory responses and antioxidant status following acute myocardial infarction through the expression of PPAR‑γ and Bcl‑2 in model mice.
|
29115547 |
2018 |
|
Acute myocardial infarction
|
0.080 |
Biomarker
|
disease |
BEFREE |
This was accompanied by significantly increased levels of phosphorylated (p)‑PI3K, p‑AKT, p‑GSK3β and Bcl‑2, as well as significantly decreased levels of caspase3, cleaved‑caspase3 and Bax following MI.
|
29845252 |
2018 |
|
Acute myocardial infarction
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Compared with AMI group and AMI + E group, in the AMI + PLV-PI3KCG group, left ventricular end diastolic diameter (LVEDd) was decreased, left ventricular ejection fraction (LVEF%) was significantly increased, and vascular endothelial growth factor (VEGF) expression was significantly increased in the infarct region (P<0.05); PI3KCG, pAkt/Akt, HIF-1a, and Bcl-2/Bax protein expressions were significantly increased (P<0.05).
|
29607167 |
2018 |
|
Acute myocardial infarction
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Using acute myocardial infarction rat models, we found that a combination therapy of CaSR inhibition and embryonic stem cell (ESC) transplantation after acute myocardial infarction (AMI) leads to a dramatic reduction in the infarct size; a significant increase in the maximum rising and falling rate (+dp/dtmax and -dp/dtmax, respectively) of left ventricular pressure; a significant decrease in left ventricular end-diastolic pressure; a significant decrease in the mRNA expression level of CaSR, Bax, Bcl-2, cleaved caspase-3, cleaved caspase-9, p-ERK, p-JNK and p-P38 protein together with apoptosis indexes in the C and E groups; and a significant decrease in cTnT levels as well as LDH and CK activity.
|
28281186 |
2017 |
|
Acute myocardial infarction
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In addition, it suppressed matrix metallopeptidase‑9, transforming growth factor‑β, p38 mitogen‑activated protein kinases (MAPK) and nuclear factor (NF)‑κB protein expression, and promoted B‑cell lymphoma 2 (Bcl‑2) protein expression in AMI mice.
|
28713946 |
2017 |
|
Acute myocardial infarction
|
0.080 |
Biomarker
|
disease |
BEFREE |
One group underwent AMI (n = 22), another AMI and L6-WT sheet transplantation (n = 17), and a third AMI and L6-Bcl2 sheet transplantation (n = 20).Five rats underwent a sham operation.
|
20089207 |
2010 |