|
Hodgkin Disease
|
0.550 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).
|
21037568 |
2010 |
|
Hodgkin Disease
|
0.550 |
Biomarker
|
disease |
BEFREE |
In addition, c-rel has been activated by a retroviral promoter insertion in an avian B-cell lymphoma, and amplifications of REL (human c-rel) are frequently seen in Hodgkin's lymphomas and diffuse large B-cell lymphomas, and in some follicular and mediastinal B-cell lymphomas.
|
14755244 |
2004 |
|
Hodgkin Disease
|
0.550 |
AlteredExpression
|
disease |
LHGDN |
Our results demonstrate that there is differential c-REL protein expression in cHL in comparison with NLPHL and suggest that c-REL may play a role in the pathogenesis of classic Hodgkin lymphoma.
|
15551733 |
2004 |
|
Hodgkin Disease
|
0.550 |
Biomarker
|
disease |
BEFREE |
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.
|
12478664 |
2003 |
|
Hodgkin Disease
|
0.550 |
AlteredExpression
|
disease |
LHGDN |
Our data confirm previous cytogenetic results from primary Hodgkin's tumors suggesting an important pathogenic role of REL and JAK2 in this disease.
|
12478664 |
2003 |
|
Hodgkin Disease
|
0.550 |
GeneticVariation
|
disease |
LHGDN |
Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.
|
11830502 |
2002 |
|
Hodgkin Disease
|
0.550 |
Biomarker
|
disease |
BEFREE |
BCL11A coamplified with REL in B-NHL cases and HD lymphoma cell lines with gains and amplifications of 2p13, suggesting that BCL11A may be involved in lymphoid malignancies through either chromosomal translocation or amplification.
|
11719382 |
2001 |
|
Hodgkin Disease
|
0.550 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
HLA-C rs12212594 T/C, JAM2 rs2829866 A/T and REL rs702873 G/A polymorphisms were not associated with the risk of RA.
|
24566686 |
2014 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA.
|
23106574 |
2013 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
The rs13017599 polymorphism is known to associate with rheumatoid arthritis (RA), and another SNP near REL (rs702873) was recently implicated in PsV susceptibility.
|
22170493 |
2012 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.460 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
The REL gene, a key modulator of the NFκB pathway, is associated with PsA but the allele conferring risk to RA is protective in PsA suggesting that there are fundamental differences in the aetiological mechanisms underlying these two types of inflammatory arthritis.
|
22328738 |
2012 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.460 |
Biomarker
|
disease |
BEFREE |
In particular, recent discoveries highlight the importance of the CD40/NF-kappaB signaling pathway in RA, based on genetic association with several genes relevant to this pathway, including CD40, TRAF1, TNFAIP3, and REL.
|
20192992 |
2010 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.460 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Rheumatoid Arthritis
|
0.460 |
Biomarker
|
disease |
CTD_human |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |