|
Heart failure
|
0.400 |
Biomarker
|
disease |
CTD_human |
Captopril therapy for severe CHF: hypotensive response in presence of markedly elevated PRA.
|
7034517 |
1982 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
CTD_human |
Mechanisms of sodium retention in heart failure: relation to the renin-angiotensin-aldosterone system.
|
1647690 |
1991 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the renin-angiotensin system in heart failure and hypertrophy--studies in human hearts and transgenic rats.
|
7713116 |
1994 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, the expression of the cardiac ACE but not of human heart chymase is upregulated in failing human heart indicating an activation of the cardiac renin-angiotensin system in patients with advanced heart failure.
|
8040271 |
1994 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
This manuscript also provides a brief update on the organization of the renin-angiotensin-aldosterone system and other angiotensin-II-forming pathways with special relevance to heart failure.
|
8835867 |
1996 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
1.The crucial role played by the renin-angiotensin-aldosterone system in the cardiovascular system and the immense therapeutic potential of angiotensin-converting enzyme inhibitors and, more recently, angiotensin II receptor blocking agents, in both heart failure and post-myocardial infarction is becoming increasingly evident.
|
9486084 |
1997 |
|
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The DD allele frequency is lower in Chinese, but the M235T variant of the angiotensinogen gene is more common in Chinese than whites; it is not known to what extent polymorphisms of the renin-angiotensin system affect clinical status or prognosis in Chinese patients with heart failure.
|
10097225 |
1999 |
|
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The activity of the cardiac renin-angiotensin system is altered in human heart failure, but the regulatory mechanisms are unknown.
|
10619441 |
1999 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
The renin-angiotensin-aldosterone system (RAS) plays a pivotal role in the cardiovascular system, and the therapeutic agents which interact with this pathway have a significant impact in both heart failure and following myocardial infarction (MI).
|
11256587 |
2000 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the renin-angiotensin and sympathetic nervous systems adversely affect heart failure progression.
|
11273991 |
2001 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Indeed, the development of hypertension as well as the progression of coronary artery disease and heart failure have two factors in common: (1) display distinct gender specific characteristics and (2) are enhanced by the renin-angiotensin system.
|
11861038 |
2002 |
|
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To assess whether renin-angiotensin-aldosterone (RAA) system gene polymorphisms shown to be associated with alterations in the activity of the system, may predict cardiac function changes subsequent to initiating medical therapy in heart failure.
|
12031704 |
2002 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Modulation of the renin-angiotensin system, particularly inhibition of the angiotensin-converting enzyme (ACE), has become a prime strategy in the treatment of hypertension and heart failure.
|
12700890 |
2003 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
The renin-angiotensin system: the role of inhibitors, blockers, and genetic polymorphisms in the treatment and prevention of heart failure.
|
15320851 |
2003 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hearts from hypertensive homozygous renin-overexpressing (Ren-2) rats that had progressed to early HF were compared by microarray analysis to Ren-2 rats that had remained compensated.
|
15284191 |
2004 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since overactivity of the renin-angiotensin system contributes to the progression of heart failure, this investigation assessed changes in gene expression of ACE2, ACE, AT1 receptor and renin in the human failing heart.
|
15151696 |
2004 |
|
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies on polymorphisms of the renin-angiotensin-aldosterone system (RAAS), adrenergic receptor polymorphisms, endothelin (receptor) polymorphisms, and a group of miscellaneous polymorphisms that may be involved in the development or phenotypic expression of heart failure will be reviewed.
|
15545741 |
2005 |
|
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of the renin-angiotensin system and mast cell density but not of angiotensin-converting enzyme II in late stages of human heart failure.
|
16962475 |
2006 |
|
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The hypothesis that intracrine renin-angiotensin system activated during heart failure is part of the tendency of the heart to return to embryological conditions when organogenesis is possible is presented and discussed.
|
16325280 |
2006 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
We hypothesized the genetic polymorphisms in the sympathetic nervous and renin-angiotensin systems are associated with adverse outcomes, defined as death or heart transplantation in patients with HF.
|
17223428 |
2007 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
There is convincing clinical and experimental evidence that the renin-angiotensin system (RAS) and its primary effector peptide, angiotensin II, are linked to the pathophysiology of interstitial fibrosis, cardiac remodeling, and heart failure.
|
17430683 |
2007 |
|
Heart failure
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We tested for a difference in prevalence of 10 renin-angiotensin-aldosterone system (RAAS)-related gene polymorphisms between a homogenous population of HF patients and healthy controls.
|
18279468 |
2008 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
BEFREE |
In a canine-pacing model of heart failure, systemic infusion of ASBNP.1 did not alter mean arterial pressure but increased the glomerular filtration rate (GFR), suppressed plasma renin and angiotensin, while inducing natriuresis and diuresis.
|
19541613 |
2009 |
|
Heart failure
|
0.400 |
Biomarker
|
disease |
CTD_human |
Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure.
|
20811386 |
2010 |
|
Heart failure
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There is compelling evidence to indicate an important role for increased local renin-angiotensin system activity in the pathogenesis of cardiac hypertrophy and heart failure.
|
20429690 |
2010 |