|
11-Beta-hydroxylase deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A 46,XX girl presented with genital ambiguity and low renin hypertension; her 46,XY brother presented with precocious puberty.Hormonal studies suggested 11β-OHD.
|
27316665 |
2016 |
|
21-hydroxylase deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
All patients with SW 21-OHD had elevated plasma renin activity.
|
28392195 |
2018 |
|
Abnormal behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The Involvement of Renin-Angiotensin System in Lipopolysaccharide-Induced Behavioral Changes, Neuroinflammation, and Disturbed Insulin Signaling.
|
31001119 |
2019 |
|
Abnormal behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The renin-angiotensin system (RAS) is implicated in the response to physiological and psychosocial stressors, but its role in stress-related psychiatric disorders is poorly understood.
|
22703619 |
2012 |
|
Abnormality of the skeletal system
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter-Cre transgene.
|
17922144 |
2007 |
|
Abnormality of the urinary system
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acromegaly
|
0.030 |
Biomarker
|
disease |
BEFREE |
Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients.
|
28166592 |
2017 |
|
Acromegaly
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The pathogenesis of increased blood pressure (BP) in acromegaly is unclear, and the role of IGF-I levels and the renin-angiotensin-aldosterone system (RAAS) in this disease remains controversial.
|
17003099 |
2006 |
|
Acromegaly
|
0.030 |
Biomarker
|
disease |
BEFREE |
Whether the renin-angiotensin-aldosterone system plays a role or not in the development of cardiovascular morbidity in acromegaly patients is unknown.
|
28712073 |
2017 |
|
ACTH Syndrome, Ectopic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, if plasma renin activity and aldosterone are both low, rare causes of mineralocorticoid excess such as ectopic ACTH syndrome should be entertained.
|
31353410 |
2019 |
|
Acute Chest Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
Compared to the DM patients in the Taiwan ACS-FS Registry, even though reperfusion therapy was carried out in significantly fewer patients, the primary percutaneous coronary intervention (PCI) rate for ST-segment elevation myocardial infarction (STEMI) and the prescription rates of GDMT for ACS including P2Y12 inhibitors, renin-angiotensin blockers, beta-blockers, and statins were significantly higher in those in the TSOC ACS-DM Registry.
|
29844642 |
2018 |
|
Acute Chest Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
While using morphine and oxygen is associated with risks such as higher mortality and increase in the size of the infarct, respectively, several available drugs such as fibrinolytics, anticoagulants, beta-blockers, renin-angiotensin-aldosterone system inhibitors, P2Y12 inhibitors, and statins are known to be useful to treat ACS.
|
29581926 |
2018 |
|
Acute Chest Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Baseline characteristics include female sex (25%), myocardial infarction as index ACS event (74%), coronary revascularization for index ACS (80%), treatment with dual anti-platelet therapy (87%) and renin-angiotensin system inhibitors (91%), median LDL cholesterol 65 mg per deciliter, and median HbA1c 7.3%.
|
31520897 |
2019 |
|
Acute coronary insufficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction: a report from the Osaka Acute Coronary Insufficiency Study.
|
24806378 |
2014 |
|
Acute Coronary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Greater mortality in low SES patients with acute coronary syndrome is due to lack of awareness of symptoms in patients and primary care physicians, delay in reaching healthcare facilities, non-availability of thrombolysis and coronary revascularization, and the non-affordability of expensive medicines (statins, dual anti-platelets, renin-angiotensin system blockers).
|
31767015 |
2019 |
|
Acute Coronary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Impact of renin-angiotensin system blockade on the prognosis of acute coronary syndrome based on left ventricular ejection fraction.
|
31105064 |
2020 |
|
Acute heart failure
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Is plasma renin activity associated with worse outcomes in acute heart failure? A secondary analysis from the BLAST-AHF trial.
|
31646707 |
2019 |
|
Acute heart failure
|
0.060 |
Biomarker
|
disease |
BEFREE |
In turn, volume expansion and vasoconstriction are due to neurohormonal imbalance since both result from activation of the sympathetic nervous system, the renin-angiotensin-aldosterone axis and excess secretion of arginine vasopressin.Outcomes in AHF remain dismal.
|
29310997 |
2018 |
|
Acute heart failure
|
0.060 |
Biomarker
|
disease |
BEFREE |
Heart failure oral therapies (HFOTs), including beta-blockers (BB), renin-angiotensin system inhibitors (RASi) and mineralocorticoid receptor antagonists, administered before hospital discharge after acute heart failure (AHF) might improve outcome.
|
28849606 |
2018 |
|
Acute heart failure
|
0.060 |
Biomarker
|
disease |
BEFREE |
This study investigated associations between incident hyperkalemia during acute heart failure (HF) hospitalizations and changes in renin-angiotensin-aldosterone system (RAAS) inhibitors.
|
31606364 |
2019 |
|
Acute heart failure
|
0.060 |
Biomarker
|
disease |
BEFREE |
This suggests that kidney impairment in patients with AHF is related to dysregulation of the renin-angiotensin-aldosterone system.
|
22688316 |
2012 |
|
Acute heart failure
|
0.060 |
Biomarker
|
disease |
BEFREE |
Patients aged ≥ 18 years, hospitalised for AHF were stratified according to pre-admission use of renin-angiotensin-aldosterone system inhibitors and randomised (n = 1002) after stabilisation to initiate sacubitril/valsartan either ≥ 12-h pre-discharge or between Days 1-14 post-discharge.
|
31134724 |
2019 |
|
Acute Kidney Tubular Necrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of Intrarenal Renin-Angiotensin System in Human Acute Tubular Necrosis.
|
27788506 |
2016 |
|
Acute lymphocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have observed renin expression in cells from acute myeloid leukemia (AML), chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL) cases.
|
12613527 |
2002 |
|
Acute myocardial infarction
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Renin-angiotensin-aldosterone system polymorphisms: a role or a hole in occurrence and long-term prognosis of acute myocardial infarction at young age.
|
17519002 |
2007 |