|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic variants of the renin-angiotensin system (RAS) have been implicated in the progression of native kidney diseases.
|
11923700 |
2002 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Relationship between polymorphisms in the renin-angiotensin system and nephropathy in type 2 diabetic patients.
|
11938025 |
2002 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Recent advances in genetic models and newly available pharmacologic tools have allowed dissection of the mechanisms of actions of the renin-angiotensin system in hypertensive kidney disease.
|
10981064 |
2002 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Genotypes of the renin-angiotensin system have been implicated in essential hypertension and in progression of native kidney diseases, but gene effects on progression in chronic renal allograft dysfunction are unclear.
|
12548125 |
2003 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms of the renin-angiotensin system (RAS) have been implicated in the pathogenesis of nephropathy and end-stage renal disease (ESRD).
|
15012717 |
2003 |
|
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The activity of the renin-angiotensin-aldosterone system (RAAS) is elevated both in the circulation and in the renal tissue of diabetic and nondiabetic nephropathies.
|
15017527 |
2004 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms of the renin-angiotensin system genes in Brazilian patients with lupus nephropathy.
|
15934435 |
2005 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We examined an association of the three renin-angiotensin system (RAS) gene polymorphisms with renal disease and progression to ESRD in dialyzed patients.
|
16384824 |
2006 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We speculate that presymptomatic patients with normal renal function who have genetic or familial FSGS may benefit from early blockade of the renin-angiotensin axis and that this may also prevent progressive renal disease.
|
17530296 |
2007 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Angiotensin II, the most vasoactive component of the renin-angiotensin-aldosterone (RAAS) pathway, can contribute to renal disease by causing an increase in arterial blood pressure leading to glomerular injury and fibrosis.
|
18206321 |
2008 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These data confirm the key role of the renin-angiotensin system to maintain glomerular filtration rate, and highlight an association between a genetic factor and susceptibility to and prognosis of acute kidney disease.
|
19020433 |
2008 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Controlling hypertension by angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB), mechanisms that inhibit later pathway steps in the renin-angiotensin system (RAS), have clinically afforded protection against cardiac and renal disease.
|
18679781 |
2008 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease.
|
19290794 |
2009 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Clinical and experimental studies that discuss the different immune functions of the renin-angiotensin system (RAS) in kidney diseases were reviewed, with emphasis on studies of kidney transplantation.
|
19539879 |
2009 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A novel REN gene mutation resulted in an alteration in the amino acid sequence of the renin signal sequence and caused childhood anemia, polyuria, and kidney disease.
|
21084044 |
2010 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
This indicates a protective role for catalase and underscores the importance of the intrarenal renin-angiotensin system in renal disease.
|
20508664 |
2010 |
|
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In animal models for human FSGS (doxorubicin nephropathy) and increased renin-angiotensin system activity (Ren2 transgenic rats), glomerular TRPC6 expression was increased in an AngII-dependent manner.
|
21839714 |
2011 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Renin-angiotensin-aldosterone system genotypes and haplotypes affect the susceptibility to nephropathy in type 2 diabetes patients.
|
21421655 |
2011 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We investigated the renoprotective effects of valsartan according to polymorphisms of the renin-angiotensin system and transforming growth factor-b1 (TGFB1) genes in patients with chronic non-diabetic proteinuric nephropathies.
|
21303424 |
2011 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The objective of this study was dual: to investigate whether mice overexpressing renin could mimic the kinetics and the physiopathological characteristics of hypertension-induced renal disease and to identify cellular and/or molecular events characterizing the different steps of the progression of CKD.
|
23300650 |
2012 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These include: (1) the intra-renal renin-angiotensin system (RAS), one based on molecular variations in angiotensinogen; (2) the Na, K, 2Cl cotransporter (NKCC2) and its regulators in the thick ascending limb, which are associated with a variety of phenotypes consistent with a more active cotransporter in blacks; and (3) the genes for MYH9 and APOL 1, which have been associated with kidney disease in blacks.
|
23397215 |
2013 |
|
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The influence of renin-angiotensin system genotypes on the antiproteinuric response to high doses of olmesartan in non-diabetic proteinuric nephropathies.
|
24241364 |
2013 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Our data suggest the application of a renin inhibitor for preventing kidney disease progression in CKD patients.
|
24154707 |
2014 |
|
Kidney Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The activation of the renin-angiotensin-aldosterone system (RAAS) occurs in progressive kidney disease leading to hypertension.
|
27476173 |
2016 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The enzyme renin plays a key role in the RAAS cascade and an important role in the development of hypertension and progression of renal disease in ADPKD.
|
26753721 |
2016 |