|
Hyperaldosteronism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Male Clcn2<sup>R180Q/+</sup> mice have increased aldosterone:renin ratios as well as elevated blood pressure levels.
|
31727896 |
2019 |
|
Hyperaldosteronism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Impaired cortisol metabolism results in a mineralocorticoid excess-like state presenting as low renin, low aldosterone hypertension (HTN) and hypokalemia.
|
30888125 |
2019 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we identified two novel missense mutations in BSND gene causing Bartter syndrome type IV which is a genetic disease with an autosomal recessive transmission, characterized by hypokalaemia, metabolic alkalosis, an elevation in plasma renin activity and hyperaldosteronism as well as sensorineural deafness.
|
30174009 |
2018 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A plasma aldosterone concentration greater than 280 pmol/l after saline infusion was considered diagnostic for aldosteronism and the plasma renin activity was assessed to exclude patients with secondary aldosteronism from the final primary aldosteronism diagnosis.
|
29528872 |
2018 |
|
Hyperaldosteronism
|
0.100 |
Biomarker
|
disease |
BEFREE |
When compared with patients with essential hypertension, patients with PA treated with MR antagonists such that renin remained suppressed (as a proxy for insufficient MR blockade) had a significantly higher risk for incident AF; however, treatment of PA with MR antagonists to substantially increase renin (suggesting sufficient MR blockade), or with surgical adrenalectomy (to remove the source of aldosteronism), was associated with no significant difference in risk for developing AF.
|
30027227 |
2018 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cases 1 and 2 presented with hyponatremia, hyperkalemia, metabolic acidosis and elevated plasma aldosterone and plasma renin activity in the neonatal period.
|
28593901 |
2017 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Measurement of plasma aldosterone and renin concentration, or activity, is useful for selecting antihypertensive agents and detecting hyperaldosteronism in hypertensive patients.
|
28652474 |
2017 |
|
Hyperaldosteronism
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate whether a spectrum of subclinical renin-independent aldosteronism that increases risk for hypertension exists among normotensive persons.
|
29052707 |
2017 |
|
Hyperaldosteronism
|
0.100 |
Biomarker
|
disease |
BEFREE |
HyperPATH cohort analyses revealed risk allele carriers vs noncarriers had increased aldosterone/renin ratios.
|
28938457 |
2017 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prenatal treatment led to increased aldosterone levels and decreased plasma renin activity, suggesting a complex physiological response.
|
28737438 |
2017 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate a continuum of renin-independent aldosteronism and mineralocorticoid receptor activity in normotension that ranges from subtle to overtly dysregulated and autonomous.
|
28289182 |
2017 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A/C = cortisol-corrected aldosterone concentration; ACE = angiotensin-converting enzyme; APA = aldosterone-producing adenoma; APCC = aldosterone-producing cell cluster; ARB = angiotensin receptor blocker; ARR = aldosterone-to-renin ratio; AVS = adrenal venous sampling; CT = computed tomography; ENaC = epithelial sodium channel; GRA = glucocorticoid remediable aldosteronism; IHA = idiopathic hyperaldosteronism; LI = lateralization ratio; MR = mineralocorticoid receptor; MRI = magnetic resonance imaging; PA = primary aldosteronism; PRA = plasma renin activity; SRA = surgical remediable aldosteronism.
|
28332881 |
2017 |
|
Hyperaldosteronism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also identified statistically significant association of KCNK3 rs2586886 with plasma aldosterone level in MESA and demonstrated that global deletion of TASK-1 channels in mice produces a mild-hyperaldosteronism, not associated with a decrease in renin.
|
27296998 |
2016 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Refractory hyperaldosteronism in heart failure is associated with plasma renin activity and angiotensinogen polymorphism.
|
25036270 |
2015 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pseudohypoaldosteronism type 1 (PHA1) is a rare condition characterized by neonatal salt loss with elevated plasma aldosterone and renin levels.
|
23197115 |
2013 |
|
Hyperaldosteronism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Concomitant presence of rs6203 CC and rs12410453 GA genotypes synergistically increased aldosterone-to-renin ratio.
|
24006038 |
2013 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Measurement of renin activity, aldosterone, and cortisol levels in plasma help to differentiate between the causes with mineralocorticoid excess whereas the urine chloride (Cl-) concentration may reveal the basis for renal Na+ wasting and distinguish it from non-renal Na+ loss.
|
17584063 |
2007 |
|
Hyperaldosteronism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aldosterone, the principal human mineralocorticoid, is increasingly recognized as playing a significant role in cardiovascular morbidity, and its role in hypertension has recently been reevaluated with studies that suggest that increased aldosterone biosynthesis (as defined by an elevated aldosterone to renin ratio) is a key phenotype in up to 15% of individuals with hypertension.
|
15284285 |
2004 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Blood pressure increase was accompanied by elevated plasma aldosterone levels and reduced plasma renin activity.
|
12626364 |
2003 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Pseudohyperaldosteronism is characterized by a clinical picture of hyperaldosteronism with suppression of plasma renin activity and aldosterone.
|
12892318 |
2003 |
|
Hyperaldosteronism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Indeed, it is well known that renin-driven renovascular hypertension is associated with the development of hyperaldosteronism.
|
11791020 |
2002 |
|
Hyperaldosteronism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to investigate allele and genotype frequencies of the -344C/T polymorphism, located in the promoter region of the aldosterone synthase gene, in 83 patients with idiopathic low renin hypertension characterized by an increased aldosterone to renin ratio, including both patients with low renin essential hypertension (n=53) and subjects with idiopathic hyperaldosteronism (n=30), compared with 78 patients with normal to high renin essential hypertension and 126 normotensive control subjects.
|
11587161 |
2001 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Three patients had elevated plasma renin activity and hyperaldosteronism.
|
11456284 |
2001 |
|
Hyperaldosteronism
|
0.100 |
Biomarker
|
disease |
BEFREE |
This exacerbated aldosterone production in kcne1(-/-) mice is accompanied by an abnormally high plasma renin concentration, which could partly explain the hyperaldosteronism.
|
11438691 |
2001 |
|
Hyperaldosteronism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A relatively reliable screening for hyperaldosteronism is a determination of the ratio of the plasma aldosterone level to the plasma renin activity.
|
10915007 |
2000 |