|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aerobic exercise training prevents obesity and insulin resistance independent of the renin angiotensin system modulation in the subcutaneous white adipose tissue.
|
31022246 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Local renin-angiotensin system (RAS) in the pancreas is linked to the modulation of glucose-stimulated insulin secretion (GSIS) in beta cells and insulin sensitivity in target tissues, emerging as a promising tool in the prevention and/or treatment of obesity, diabetes, and systemic arterial hypertension.
|
30404071 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated renin-angiotensin system (RAS) activity in cultured circulating T-cells in subjects with obesity with and without angiotensin II (Ang II) stimulation in the presence or absence of low-grade inflammation.
|
31084908 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The cardiovascular complications associated to obesity are also driven by processes involving hormones and peptides and which include inflammation, insulin resistance, endothelial dysfunction, coronary calcification, activation of coagulation, renin angiotensin or the sympathetic nervous systems.
|
31467596 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Obesity activates the renin-angiotensin and sympathetic systems facilitating hypertension and changes in the hydroelectrolytic balance.
|
31284013 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the effect of apelin treatment on obesity-induced type 2 diabetes mellitus (T2DM) and possible interaction between apelin/APJ system and renin-angiotensin system (RAS).
|
29564917 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Obesity and aging affects skeletal muscle renin-angiotensin system and myosin heavy chain proportions in pre-diabetic Zucker rats.
|
31197649 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings improve understanding of sex differences in renin-angiotensin mechanisms in obesity and illustrate the potential for targeting angiotensin-(1-7) for treatment of this condition.
|
31315689 |
2019 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Obesity may compound the increased risk of hypertension and cardiovascular disease in individuals born prematurely by further augmenting the prematurity-associated imbalance in the renin-angiotensin system.
|
30404738 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with innumerous comorbidities, including cardiovascular diseases, that occur by various mechanisms, including hyperactivation of the renin angiotensin system, oxidative stress and cardiovascular overload.
|
30974117 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mechanisms that connect obesity and HFpEF vary from obesity-induced hemodynamic changes to important biohumoral systems such as adipocitokines, renin-angiotensin-aldosterone and sympathetic nervous systems, natriuretic peptide, and oxidative stress.
|
30610456 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Father's obesity programs the adipose tissue in the offspring via the local renin-angiotensin system and MAPKs pathways, especially in adult male mice.
|
28534168 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypertension and obesity are two significant factors that contribute to the onset and exacerbation of a cascade of mechanisms including activation of the sympathetic and renin-angiotensin systems, oxidative stress, release of inflammatory mediators, increase of adipogenesis and thus promotion of systemic dysfunction that leads to clinical manifestations of cardiovascular diseases.
|
30011911 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Perinatal renin-angiotensin system programming was more pronounced in women and individuals with overweight/obesity, thus potentially augmenting their risk of developing early cardiovascular disease.
|
29846325 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Obesity, whether defined by BMI or BF%, was not associated with a significantly increased risk of ESRD in Cox proportional hazards models that adjusted for age, sex, diabetes mellitus, cardiovascular disease, estimated glomerular filtration rate, urine protein:creatinine ratio, high-sensitivity C-reactive protein, and use of renin-angiotensin-aldosterone system inhibitors or statins, accounting for the competing risk for mortality (subdistribution HR: 1.15; 95% CI: 0.62, 2.14 for BMI-defined obesity and subdistribution HR: 0.84, 95% CI: 0.54, 1.29 for BF%-defined obesity, respectively).
|
30321257 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the renin-angiotensin-aldosterone system is over-activated in obesity.
|
29875164 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated with the inappropriate activation of the renin-angiotensin system (RAS), which increases arterial pressure, impairs insulin secretion and decreases peripheral tissue insulin sensitivity.
|
29643115 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A systemic proinflammatory state in combination with activation of the renin-angiotensin system and decreased nitric oxide bioavailability as found in obesity leads to endothelial dysfunction.
|
28615046 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A higher duration of obesity was associated with decreased U-AGT in boys, thus reflecting decreased intrarenal activity of the renin-angiotensin system.
|
28337615 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we developed a mouse model to investigate the functional relevance of the hRen-Pal3 sequence in vivo since it might be responsible for the increased renin production in obesity and thus for the development of accompanying arterial hypertension.
|
28534088 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The main goal of the present study was to evaluate the metabolic profile, inflammatory markers and the gene expression of the renin-angiotensin system (RAS) components in the visceral adipose tissue of eutrophic, obese and malnourished individuals and mice models of obesity and food restriction.
|
28779634 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prevalence of hypertension induced by obesity has grown over the years, and the role of the renin-angiotensin-aldosterone system (RAAS) in this process continues to be elucidated.
|
27940965 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activation of the renin-angiotensin-aldosterone system is common in hypertension and obesity and contributes to cardiac diastolic dysfunction, a condition for which no treatment currently exists.
|
28977602 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The renin-angiotensin system (RAS) and obesity have been implicated in vascular outward remodeling, including aneurysms, but the precise mechanisms are not yet understood.
|
28646121 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance.
|
27497523 |
2017 |