|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of the renin-angiotensin system remains a cornerstone in reducing proteinuria and progression of kidney failure, effects believed to be the result of reduction in BP and glomerular hyperfiltration.
|
31511362 |
2019 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Despite optimization of renin-angiotensin-aldosterone system (RAAS) inhibition, patients with immunoglobulin A nephropathy (IgAN) and persistent proteinuria remain at risk for kidney failure.
|
30922594 |
2019 |
|
Kidney Failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, a growing body of evidence suggests that hyperkalemia might negatively impact outcomes in the long term in patients with chronic heart failure or kidney failure through underdosing or withholding of cardiovascular medication (e.g. renin-angiotensin-aldosterone system inhibitors).
|
31800081 |
2019 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Age-associated neurohormonal changes particularly affecting the renin angiotensin aldosterone system (RAAS), alterations in thermoregulatory mechanisms, changes in renal function and body composition render older persons vulnerable to dehydration, renal failure, heat stroke and increased mortality.
|
31268494 |
2019 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
At a molecular level, the activation of the renin-angiotensin system is responsible for the development of renal fibrosis, eventually leading to renal failure.
|
29869165 |
2018 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Renin-angiotensin-aldosterone system blockade is proven to delay the onset of renal failure by reducing proteinuria.
|
28864840 |
2018 |
|
Kidney Failure
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Diabetes and hypertension are associated with an elevated risk of kidney failure while elevated HDL levels and renin-angiotensin blockade appear protective.
|
28666418 |
2017 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Renin-angiotensin system activation accelerates atherosclerosis in experimental renal failure by promoting endoplasmic reticulum stress-related inflammation.
|
28098884 |
2017 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
The currently available therapies for diabetic nephropathy, one of the leading causes of renal failure globally are based on inhibition of renin angiotensin system.
|
28943106 |
2017 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment effects of renin-angiotensin aldosterone system blockade on kidney failure and mortality in chronic kidney disease patients.
|
29187194 |
2017 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
The "Expert guidelines for the diagnosis and management of Alport syndrome" recommend treating those with albuminuria with renin-angiotensin-aldosterone system (RAAS) blockade (and adequate birth control because of the teratogenic risks of angiotensin converting enzyme inhibitors), believing that this will delay renal failure.
|
27287265 |
2016 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
We isolated transgenic BMSCs (TG-BMSCs) from young end-organ-disease-free rats with increased RAS activation [human angiotensinogen/renin double transgenic rats (dTGRs)] that eventually develop hypertension and die of end-organ damage and kidney failure at 8 weeks of age.
|
25534858 |
2015 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Her risk of renal failure is high, but the rate of progression to end-stage disease depends on the underlying mutations, and disease modification with renin-angiotensin blockade.
|
24337245 |
2014 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The recommendations include the use of genetic testing as the gold standard for the diagnosis of Alport syndrome and the demonstration of its mode of inheritance; the need to identify and follow all affected members of a family with X-linked Alport syndrome, including most mothers of affected males; the treatment of males with X-linked Alport syndrome and individuals with autosomal recessive disease with renin-angiotensin system blockade, possibly even before the onset of proteinuria; discouraging the affected mothers of males with X-linked Alport syndrome from renal donation because of their own risk of kidney failure; and consideration of genetic testing to exclude X-linked Alport syndrome in some individuals with thin basement membrane nephropathy.
|
23349312 |
2013 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Homozygous or compound heterozygous mutations in renin (REN) cause renal tubular dysgenesis, which is characterized by death in utero due to kidney failure and pulmonary hypoplasia.
|
21903317 |
2011 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
The renin-angiotensin system genes, cytokine-encoding genes, and plasminogen activator inhibitor type 1 genes have been implicated in calcineurin inhibitor-induced nephrotoxicity, as well as in development of renal failure.
|
20099993 |
2010 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
This alters the intrarenal renin-angiotensin system and the juxtaglomerular apparatus functionality and leads to nephron dropout and progressive kidney failure.
|
19664745 |
2009 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been suggested that inappropriate stimulation of the renin-angiotensin system (RAS) is responsible for the increase in blood pressure that occurs in autosomal-dominant polycystic kidney disease (ADPKD) before the development of renal failure.
|
16612257 |
2006 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension.
|
15662219 |
2005 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Renin-angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis.
|
15789057 |
2005 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In some studies genetic variation in the renin-angiotensin-aldosterone system (RAAS) has been associated with hypertension and rapid progression of renal insufficiency to end-stage renal disease (ESRD).
|
12832734 |
2003 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
The genes of the renin-angiotensin system (RAS) are involved in progression of renal failure.
|
12187084 |
2002 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, experimental evidence was presented that genetic manipulation of peptide systems (i.e., the renin-angiotensin II system and the kallikrein-kinin system) was effective in the treatment of systemic cardiovascular diseases such as hypertension, heart failure, and renal failure.
|
11773594 |
2001 |
|
Kidney Failure
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many studies have attempted to relate genetic variants of components of the renin-angiotensin system to complex diseases such as essential hypertension, cardiovascular disease and progressive renal failure.
|
11195043 |
2001 |
|
Kidney Failure
|
0.100 |
Biomarker
|
disease |
BEFREE |
In autosomal dominant polycystic kidney disease 1) the genetic localization of the defective gene that causes type 1 disease has been narrowed to 500 to 750 kb on chromosome 16; 2) cystogenesis has been associated with increased cell proliferation, continuing cyst secretion, and a defect in cell polarity; however, the mechanisms by which the genetic defects in autosomal dominant polycystic kidney disease translate into cyst formation are unknown; 3) activation of the renin system has been reported as an important potential cause of hypertension; and 4) factors that influence the progression to renal failure have been identified.
|
7922177 |
1993 |