|
Resistant hypertensive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Resistant hypertension (RHTN) is defined as uncontrolled blood pressure despite the use of ≥3 antihypertensive agents of different classes, including a diuretic, usually thiazide-like, a long-acting calcium channel blocker, and a blocker of the renin- angiotensin system, either an ACE (angiotensin-converting enzyme) inhibitor or an ARB (angiotensin receptor blocker), at maximal or maximally tolerated doses.
|
30920924 |
2019 |
|
Resistant hypertensive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dysregulation is evident in hypertension (primary aldosteronism), low renin, and resistant hypertension) but also can exist in normotension.
|
30580687 |
2019 |
|
Resistant hypertensive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sympathetic overactivity and chronic activation of the renin-angiotensin system are salient features of resistant hypertension.
|
31654065 |
2019 |
|
Resistant hypertensive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interpreting stimulated plasma renin and aldosterone to select physiologically individualized therapy for resistant hypertension: importance of the class of stimulating drugs.
|
31562418 |
2019 |
|
Resistant hypertensive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Participants with unCH using ≤ 2 drugs had low usage of renin-angiotensin system blockers (36.8%) and diuretics (5.5%), which was much lower than participants with CH using ≤3 drugs and RH (P< 0.05).
|
29509105 |
2018 |
|
Resistant hypertensive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a long-acting calcium channel blocker, a blocker of the renin-angiotensin system (angiotensin-converting enzyme inhibitor or angiotensin receptor blocker), and a diuretic.
|
30354828 |
2018 |
|
Resistant hypertensive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Resistant hypertension is a common clinical problem in South Africa and is frequently associated with low renin and aldosterone levels, especially in black Africans.
|
29144530 |
2017 |
|
Resistant hypertensive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review aims to provide a simplified work-up for patients with resistant HT, summarize the rationale for the determination of renin and aldosterone levels, and critically discuss available evidence on when and how to measure renin/aldosterone in resistant HT.
|
28462715 |
2017 |
|
Resistant hypertensive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.
|
28052878 |
2017 |
|
Resistant hypertensive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
African and African American hypertensives tend to retain salt and water, with lower levels of plasma renin and more resistant hypertension.
|
28472315 |
2017 |
|
Resistant hypertensive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The pathophysiology underlying RH is complex, involving multiple, overlapping contributors including activation of the renin-angiotensin aldosterone system and the sympathetic nervous system, volume overload, endothelial dysfunction, behavioural and lifestyle factors.
|
28349377 |
2017 |
|
Resistant hypertensive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
They are characterized in the majority of cases by early onset, severe or resistant hypertension and associated with suppressed renin levels.
|
26303089 |
2015 |
|
Resistant hypertensive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA samples from the proband with early-onset, treatment-resistant hypertension and suppressed plasma renin activity were initially screened for mutations in the C-terminal exons of the ENaC β or γ subunit genes, using amplification by polymerase chain reaction and direct DNA sequencing.
|
22613642 |
2012 |
|
Resistant hypertensive disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that unfavorable genetic renin-angiotensin-aldosterone system patterns and clinical risk variables may contribute to increasing the risk for the development of resistant hypertension in a sample of the Brazilian population.
|
17334527 |
2007 |
|
Resistant hypertensive disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypertensive patients with low renin and aldosterone, hypokalemia or resistant hypertension were selected for DNA analysis.
|
12714866 |
2003 |
|
Resistant hypertensive disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA samples from two probands with early-onset, treatment-resistant hypertension and suppressed plasma renin activity were initially screened for mutations in the C-terminal exons of the ENaC or subunit genes, using amplification by polymerase chain reaction and direct DNA sequencing.
|
12473862 |
2002 |