|
Renal Insufficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To address this, we aimed to determine the effect of deoxycorticosterone acetate (DOCA) -salt (sodium chloride)-induced hypertension on the alterations in renin-angiotensin system, leading to CV and renal dysfunction in uninephrectomized male Sprague Dawley rats.
|
30290168 |
2019 |
|
Renal Insufficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, ET<sub>A</sub>/ET<sub>B</sub> receptor antagonism represents a promising therapeutic approach to hypertension, especially with low-renin characteristics, and could be used in combination with RAS blockers, without increasing the risk of renal impairment.
|
30622171 |
2019 |
|
Renal Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of the brain renin-angiotensin system by oral APA inhibitor is at least as effective as oral AT1R blocker to inhibit cardiac dysfunction after MI but without hypotension or renal dysfunction.
|
30531435 |
2019 |
|
Renal Insufficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In type 1 diabetes (T1D), adjuvant treatment with inhibitors of the renin-angiotensin-aldosterone system (RAAS), which dilate the efferent arteriole, is associated with prevention of progressive albuminuria and renal dysfunction.
|
29321380 |
2018 |
|
Renal Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
Losartan prevents the imbalance between renal dopaminergic and renin angiotensin systems induced by fructose overload. l-Dopa/dopamine index as new potential biomarker of renal dysfunction.
|
29727629 |
2018 |
|
Renal Insufficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hence in this study, we aimed to determine the effect of high salt diet on the alterations of renin-angiotensin system and microRNAs leading to CV and renal dysfunction in uninephrectomized rats.
|
28727756 |
2017 |
|
Renal Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
While the involvement of the renin-angiotensin-aldosterone system and the sympathetic nervous system in the progression of cardiovascular, pulmonary, and renal dysfunction in experimental and clinical CHF is well established, the importance of pro-inflammatory mediators in the pathogenesis of this clinical setting is still evolving.
|
28674538 |
2017 |
|
Renal Insufficiency
|
0.100 |
Biomarker
|
disease |
BEFREE |
This suggests that kidney impairment in patients with AHF is related to dysregulation of the renin-angiotensin-aldosterone system.
|
22688316 |
2012 |
|
Renal Insufficiency
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased activation of the renin-angiotensin system (RAS) may be important in promoting coronary heart disease (CHD) and renal dysfunction, but limited data are available on associations between angiotensin type 1 receptor (AGT1R) and angiotensinogen (AGT) genotypes in type 2 diabetes.
|
19327134 |
2009 |
|
Renal Insufficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association of renin-angiotensin system (RAS) polymorphisms and left-ventricular hypertrophy (LVH) may depend on the presence of risk factors for LVH, such as renal dysfunction.
|
17903694 |
2007 |
|
Renal Insufficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension.
|
15662219 |
2005 |
|
Renal Insufficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Renin-angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis.
|
15789057 |
2005 |
|
Renal Insufficiency
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In some studies genetic variation in the renin-angiotensin-aldosterone system (RAAS) has been associated with hypertension and rapid progression of renal insufficiency to end-stage renal disease (ESRD).
|
12832734 |
2003 |