Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results revealed that six key pathways might be associated with longevity, including the longevity-regulating pathway, the peroxisome pathway, the mTOR-signalling pathway, the FOXO-signalling pathway, the AGE-RAGE-signalling pathway in diabetic complications, and the TGF-beta-signalling pathway.
|
31327054 |
2019 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
In particular, ceramides and triglycerides with saturated fatty acids and monounsaturated fatty acids were significantly changed by YJT, which were significantly associated with insulin resistance, the AGE-RAGE signaling pathway in diabetic complications and adipocytokine signaling pathway in pathway enrichment analysis.
|
31088684 |
2019 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Kyoto Encyclopedia of Genes and Genomes analysis showed that target genes of miR-4792 were enriched in aminoacyltRNA biosynthesis, AGE-RAGE signaling pathway in diabetic complications, sphingolipid signaling pathway, neuroactive ligand-receptor interaction, glycosaminoglycan degradation, and regulation of lipolysis in adipocytes.
|
30863107 |
2019 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
These indicated that quercetin produced the therapeutic effects against cardiovascular disease by systemically and holistically regulating many signaling pathways, including Fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, MAPK signaling pathway, IL-17 signaling pathway and PI3K-Akt signaling pathway.
|
31573877 |
2019 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, 1730 genes were differentially expressed (DGEs), 9 up-regulated pathways (protein digestion and absorption, neuroactive ligand-receptor interaction, pancreatic secretion, tyrosine metabolism, amoebiasis, ECM-receptor interaction, riboflavin metabolism, amino sugar and nucleotide sugar metabolism and AGE-RAGE signaling pathway in diabetic complications) were significantly enriched ( q < 0.05), and one down-regulated pathway ( Staphylococcus aureus infection) was significantly enriched ( q < 0.05).
|
29425446 |
2018 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Checking and maintaining low glycated albumin levels would prevent the formation of AGE and may be useful to prevent the onset or progression of diabetes complications.
|
28504612 |
2018 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, five KEGG pathways were significantly enriched, including ECM-receptor interaction, amoebiasis, AGE-RAGE signaling pathway in diabetic complications, focal adhesion, protein digestion and absorption.
|
30568862 |
2018 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The AGE receptors 1, 2 and 3, which are encoded by DDOST, PRKCSH and LGALS3, respectively, may be involved in the pathogenesis of diabetic complications.
|
20490454 |
2010 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
AGE contribute to the pathogenesis of diabetic complications, including dyslipidaemia and atherosclerosis.
|
17579831 |
2007 |
Complications of Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although several gene polymorphisms are detected in most AGE-R components, no significant correlation to diabetic complications has as yet been found.
|
11757079 |
2002 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
AGE-R2 and -R3 mRNA and protein levels were enhanced in both T1D groups (DC > n-DC) (n-DC AGE-R3, p < .05, DC AGE-R3, p < .05) compared to NL.
|
11471552 |
2001 |