Cardiomyopathy, Familial Idiopathic
|
0.320 |
Biomarker
|
disease |
BEFREE |
Here, in this study, our data showed that APS can promote proliferation and decrease apoptosis in AGE-induced DCM cell model, besides, APS can decrease intracellular ROS level, increase activity of SOD, GSH-Px and lower level of MDA and NO in DCM cell model, indicating APS exerted antioxidative function in DCM model cells.
|
29607874 |
2018 |
Cardiomyopathy, Familial Idiopathic
|
0.320 |
Biomarker
|
disease |
CTD_human |
Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes.
|
12612874 |
2003 |
Cardiomyopathy, Familial Idiopathic
|
0.320 |
Biomarker
|
disease |
BEFREE |
Furthermore, RBP-jkappa may be a useful diagnostic marker for DCM.
|
10600520 |
1999 |
Cardiomyopathy, Dilated
|
0.300 |
Biomarker
|
group |
CTD_human |
Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes.
|
12612874 |
2003 |
Schizophrenia
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to examine grey matter differences between controls and siblings of patients with schizophrenia and to examine whether the age, genetic loading or subclinical psychotic symptoms of selected individuals could explain the previously reported inconsistencies.
|
25768029 |
2015 |
Schizophrenia
|
0.130 |
GeneticVariation
|
disease |
BEFREE |
Our findings identified a new schizophrenia susceptibility locus on Xq28, which harbor the genes RENBP, MECP2, and ARHGAP4.
|
24043878 |
2014 |
Schizophrenia
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.
|
24043878 |
2014 |
Schizophrenia
|
0.130 |
GeneticVariation
|
disease |
GWASDB |
Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.
|
24043878 |
2014 |
Schizophrenia
|
0.130 |
Biomarker
|
disease |
BEFREE |
RBP-7000 is a sustained-release (once-monthly injection for subcutaneous administration) formulation of risperidone using the ATRIGEL® Delivery System, developed for treatment of schizophrenia to address compliance issues associated with oral administration.
|
23868656 |
2013 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is accumulating evidence that the AGEs-RAGE interaction plays an important role in accelerated atherosclerosis in diabetes.
|
31378770 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
There is accumulating evidence that the AGEs-RAGE interaction plays an important role in accelerated atherosclerosis in diabetes.
|
31378770 |
2019 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results revealed that six key pathways might be associated with longevity, including the longevity-regulating pathway, the peroxisome pathway, the mTOR-signalling pathway, the FOXO-signalling pathway, the AGE-RAGE-signalling pathway in diabetic complications, and the TGF-beta-signalling pathway.
|
31327054 |
2019 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
In particular, ceramides and triglycerides with saturated fatty acids and monounsaturated fatty acids were significantly changed by YJT, which were significantly associated with insulin resistance, the AGE-RAGE signaling pathway in diabetic complications and adipocytokine signaling pathway in pathway enrichment analysis.
|
31088684 |
2019 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Kyoto Encyclopedia of Genes and Genomes analysis showed that target genes of miR-4792 were enriched in aminoacyltRNA biosynthesis, AGE-RAGE signaling pathway in diabetic complications, sphingolipid signaling pathway, neuroactive ligand-receptor interaction, glycosaminoglycan degradation, and regulation of lipolysis in adipocytes.
|
30863107 |
2019 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
These indicated that quercetin produced the therapeutic effects against cardiovascular disease by systemically and holistically regulating many signaling pathways, including Fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, MAPK signaling pathway, IL-17 signaling pathway and PI3K-Akt signaling pathway.
|
31573877 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the role of PKCδ in cardiac and mitochondrial dysfunction caused by AGE in diabetes is still unclear.
|
30090653 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
AGE cannot replace HbA1c for the diagnosis and management of diabetes because there is no correlation of AGE with serum glucose, and because the half-life of protein with which glucose combines is only 14-20 days as compared to erythrocytes which have a half-life of 90-120 days.
|
30179123 |
2018 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Through the detection of protein expression, EGCG was observed to possess the ability to downregulate the accumulation of AGE-RAGE in pancreatic tissues as well as in the transcription factor nuclear factor-κB (NF-κB), which represents a potentially significant method by which EGCG influences diabetes.
|
30582209 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to assess the validity of our experimental procedures for measuring AGEs in stored blood sample and to conduct a pilot study for developing AGE biomarkers for diabetes and/or age-related changes of glucose metabolism.
|
29718545 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
AGE cannot replace HbA1c for the diagnosis and management of diabetes because there is no correlation of AGE with serum glucose, and because the half-life of protein with which glucose combines is only 14-20 days as compared to erythrocytes which have a half-life of 90-120 days.
|
30179123 |
2018 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Through the detection of protein expression, EGCG was observed to possess the ability to downregulate the accumulation of AGE-RAGE in pancreatic tissues as well as in the transcription factor nuclear factor-κB (NF-κB), which represents a potentially significant method by which EGCG influences diabetes.
|
30582209 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the role of PKCδ in cardiac and mitochondrial dysfunction caused by AGE in diabetes is still unclear.
|
30090653 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The objective of this study was to assess the validity of our experimental procedures for measuring AGEs in stored blood sample and to conduct a pilot study for developing AGE biomarkers for diabetes and/or age-related changes of glucose metabolism.
|
29718545 |
2018 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, 1730 genes were differentially expressed (DGEs), 9 up-regulated pathways (protein digestion and absorption, neuroactive ligand-receptor interaction, pancreatic secretion, tyrosine metabolism, amoebiasis, ECM-receptor interaction, riboflavin metabolism, amino sugar and nucleotide sugar metabolism and AGE-RAGE signaling pathway in diabetic complications) were significantly enriched ( q < 0.05), and one down-regulated pathway ( Staphylococcus aureus infection) was significantly enriched ( q < 0.05).
|
29425446 |
2018 |
Complications of Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Checking and maintaining low glycated albumin levels would prevent the formation of AGE and may be useful to prevent the onset or progression of diabetes complications.
|
28504612 |
2018 |