RET, ret proto-oncogene, 5979

N. diseases: 607; N. variants: 162
Disease: Thyroid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Medullary thyroid carcinoma in a child with a new RET mutation and a RET polymorphism. 15844786 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Incidentally simultaneous occurrence of RET/PTC, H4-PTEN and BRAF mutation in papillary thyroid carcinoma. 18226854 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE These targets include the proto-oncogenes BRAF and RET, known to be common mutations in thyroid cancer; vascular endothelial growth factor receptor and platelet-derived growth factor receptor, associated with angiogenesis; and the sodium-iodide symporter, with the aim of restoring its expression and hence radioactive iodine uptake. 20142332 2010
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations: identification of new signaling elements. 18756447 2009
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Intronic single nucleotide polymorphisms in the RET protooncogene are associated with a subset of apparently sporadic pheochromocytoma and may modulate age of onset. 14557473 2003
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Germline homozygous mutations at codon 804 in the RET protooncogene in medullary thyroid carcinoma/multiple endocrine neoplasia type 2A patients. 15741265 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Three novel mutations in the RET proto-oncogene. 11692159 2001
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Exon 5 of the RET proto-oncogene: a newly detected risk exon for familial medullary thyroid carcinoma, a novel germ-line mutation Gly321Arg. 16419493 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population. 9861322 1998
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Papillary thyroid carcinoma in patients with RET proto-oncogene germline mutation. 12193298 2002
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Thyroid cancer is frequently associated with the oncogenic conversion of the RET receptor tyrosine kinase. 16778204 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Significance of the RET proto-oncogene polymorphisms in Turkish sporadic medullary thyroid carcinoma patients. 17185892 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Molecular analysis of the RET and NTRK1 gene rearrangements in papillary thyroid carcinoma in the Polish population. 16483615 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE BRAF(V600E) mutation analysis is superior to RAS point mutations and evaluation of RET/PTC rearrangements in the diagnosis of thyroid cancer, even in indeterminate lesions. 25333496 2015
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangements. 17464312 2007
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Nevertheless, an extensive molecular analysis that included all codons was prompted by the diagnosis of thyroid neoplasm in a patient's sister, and identified the rare intracellular RET p.Ser891Ala mutation. 23295303 2012
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN These results suggest that, if the association between HT and thyroid cancer exists, its molecular basis is different from RET/PTC rearrangement. 11927965 2002
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Since fine-needle aspiration biopsy (FNAB) is an important component of the preoperative management of patients with thyroid tumors, we developed a rapid (20-min) method that enables extraction of DNA from FNABs for RET mutation analysis. 9824378 1998
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Rearrangements of the RET receptor tyrosine kinase gene generating RET/PTC oncogenes are specific to papillary thyroid carcinoma (PTC), the most frequent thyroid tumor. 16203990 2005
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Here we describe the first evidence of ret proto-oncogene rearrangement of thyroid cancer tissues around the site. 10551507 1999
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN A new germline point mutation in Ret exon 8 (cys515ser) in a family with medullary thyroid carcinoma. 18631007 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE A G691S RET polymorphism was present with a higher frequency in radiation-induced epithelial thyroid tumours (55%) than in sporadic tumours (20%) and in control normal thyroid tissues (15%). 12085189 2002
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE The catalytic domain of RET can be used also for X-ray diffraction to obtain information about the three-dimensional structure, necessary for a rational design of selective inhibitors: it represents an important tool to understand the molecular mechanisms causing thyroid cancer and to care it. 16490247 2006
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease LHGDN The RET IVS1-126G>T variant is strongly associated with the development of sporadic medullary thyroid cancer. 15142370 2004
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.700 GeneticVariation disease BEFREE Germline RET proto-oncogene mutations are the genetic causes of multiple endocrine neoplasia type 2 and a strong genotype-phenotype correlation exists, particularly between a specific RET codon mutation and the (a) age-related onset and (b) thyroid tumor progression, from C-cell hyperplasia to medullary thyroid carcinoma and, ultimately, to nodal metastases. 22584703 2012