Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Identification of a novel subtype of H4-RET rearrangement in a thyroid papillary carcinoma and lymph node metastasis.
|
10675479 |
2000 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements involving the RET gene are common in radiation-associated papillary thyroid cancer (PTC).
|
11021799 |
2000 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge, this case represents the first documented case of concurrent lymph node metastases of MTC and PTC in a patient with RET proto-oncogene germline mutation.
|
14586073 |
2003 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Activating mutations of the oncogene BRAF or rearrangements of the tyrosine kinase receptor RET are observed in up to 80% of papillary thyroid carcinomas (PTCs).
|
20652698 |
2010 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In papillary thyroid carcinogenesis, the constitutively activated mitogen-activated protein (MAP) kinase signaling pathway caused by a genetic alteration such as RET/PTC rearrangement or mutation of RAS and BRAF genes, is thought to be a major early event.
|
17186541 |
2007 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This genomic region contains the RET oncogene, which has been implicated in the pathogenesis of multiple endocrine neoplasia types 2A and 2B, Hirschsprung disease, and medullary and papillary thyroid carcinomas.
|
8818661 |
1996 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also found that among ABS, the frequency of PTC cases with no detectable gene alterations in RET, neurotrophic tyrosine kinase receptor 1 (NTRK1), BRAF, or RAS was significantly higher in patients with relatively higher radiation exposure than those with lower radiation exposure.
|
23050789 |
2012 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas.
|
10439047 |
1999 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ELE1/RET is related to the solid variant of PTC, H4/RET more frequently to typical papillary structures.
|
10741739 |
2000 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A novel type of RET rearrangement (PTC8) in childhood papillary thyroid carcinomas and characterization of the involved gene (RFG8).
|
11156407 |
2000 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We previously reported high frequency (6/11) of rearrangement of the RET protooncogene in Chinese PTCs.
|
11216646 |
2000 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A weak association between RET polymorphisms and sporadic papillary thyroid carcinoma (PTC) has also been described.
|
19411807 |
2009 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
One papillary thyroid cancer without RET mutations was detected by clinical screening.
|
23744765 |
2013 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The expression of genes encoding CCL20, CXCL8 and l-selectin was significantly higher in PTC specimens (either with RET/PTC, BRAF(V600E) or unknown genetic lesion) compared with normal thyroid samples.
|
20447069 |
2010 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
XRCC1 T-77C polymorphism affects the genetic susceptibility for PTC development in men, the specific combination of XRCC1 haplotypes correlates with RET/PTC incidence, CDKN1B Val109Gly significantly influences the risk of developing PTC regardless of gender and in PTC cases, selected genotypes of TP53 Arg72Pro and ATM Asp1853Asn were significantly associated with monitored tumour characteristics.
|
27314298 |
2016 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Classic genetic rearrangements in papillary carcinoma of the thyroid involve the RET- or TRK proto-oncogenes.
|
11678839 |
2001 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Detection of RET/PTC oncogene rearrangements in Korean papillary thyroid carcinomas.
|
10646664 |
1999 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET.
|
29436694 |
2018 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutually exclusive mutations of RET, RAS, or BRAF are present in about 70% of papillary thyroid carcinomas, whereas only the latter two are seen in poorly differentiated and anaplastic cancers.
|
18381570 |
2008 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
PTC with RET/PTC rearrangement as well as the TPC-1 cell line (the only one harboring RET/PTC rearrangement) did not show the BRAF(V599E) mutation.
|
12881714 |
2003 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Primary hyperparathyroidism, C-cell hyperplasia and papillary thyroid carcinoma in a patient with RET germline polymorphism S836S.
|
12410354 |
2002 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic analysis of both tumour components showed a distinctive mutational pattern: in the MTC a Cys634Arg substitution in exon 11 of the RET gene and in the two PTC foci a Val600Glu substitution in exon 15 of the BRAF gene.
|
15947103 |
2005 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In four of these cases, BRAF mutation and RET/PTC rearrangement were coexisting.
|
22457234 |
2012 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The lesions were screened for the BRAF(V600E) and NRAS mutations and for RET/PTC and PAX8-PPARG rearrangements.
|
23966419 |
2013 |
Papillary thyroid carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Next, the expression of LIMD2 was correlated with clinical pathological parameters and BRAF V600E and RET/PTC mutational status.
|
29560564 |
2018 |