|
Follicular adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, atypia of undetermined significance/follicular lesion of undetermined significance resulted in three goitres, 10 follicular adenomas and one NIFTP whereas FN/suspicious for FN by seven follicular adenomas and 16 malignancies (nine non-invasive follicular thyroid neoplasms with papillary-like nuclear features, two invasive follicular variant of papillary thyroid carcinoma [PTC] and five PTC).
|
29683529 |
2018 |
|
Follicular adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
- To detect histologic and molecular differences separating NIFTP from follicular adenomas (FAs) and invasive carcinomas, particularly papillary carcinomas with extensive follicular growth (PTC-EFGs) and invasive encapsulated PTC-FV (IE-PTC-FV).
|
29582677 |
2018 |
|
Follicular adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Eleven of those (55%) underwent surgical resection with final diagnosis of PTC in 8 cases, follicular carcinoma in one case (5%), follicular adenoma in one case (5%), and Hurthle cell adenoma in one case (5%).
|
28261999 |
2017 |
|
Follicular adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Wild-type (nonrearranged) c-RET oncogene was overexpressed in 60% of PTC cases and absent in follicular thyroid carcinoma (FTC), anaplastic thyroid carcinoma (ATC), follicular adenomas (FA) or normal thyroid.
|
20950609 |
2011 |
|
Follicular adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF or RET/PTC mutations were always associated with cancer, whereas RAS mutations were mainly associated with cancer (74%) but also follicular adenoma (26%).
|
20130073 |
2010 |
|
Follicular adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the more aggressive UTC, the mean methylation index (MI = 0.44) was the highest compared to other thyroid alterations PTC (MI = 0.29, p = 0.123), FTC (MI = 0.15, p = 0.005), MTC (MI = 0.13; p = 0.017), FA (MI = 0.27; p = 0.075) and goiters (MI = 0.23; p = 0.024).
|
16889486 |
2006 |
|
Follicular adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The immunohistochemical results revealed that 66.7% of PTCs, 28.6% of FAs, and 18.2% of hyperplastic thyroid tissue specimens showed high levels of RET protein expression.
|
15785245 |
2005 |
|
Follicular adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Neither RAS mutation nor RET overexpression were detected in FA.
|
15588246 |
2004 |
|
Follicular adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RET was expressed in 5.4% of normal thyroid tissue, 18% of follicular adenomas, 22.7% of nodular hyperplasia cases and 71.7% of papillary carcinomas.
|
15203751 |
2004 |
|
Follicular adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study found that the RET proto-oncogene is often stimulated in FCDT, not only in PTC but also in follicular tumors (FA and FTC), and may contribute to tumorigenesis of these tumors.
|
12608895 |
2003 |
|
Follicular adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data confirm the crucial role played by the ret proto-oncogene activating rearrangements in the development of radiation-associated thyroid tumors, and show, for the first time, the presence of RET/PTC genes in follicular adenomas appeared after external irradiation.
|
9466701 |
1997 |
|
Follicular adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results confirm the crucial role played by the ret proto-oncogene activating rearrangements in the development of radiation-associated thyroid tumors appearing after therapeutic or accidental ionizing irradiation, and show, for the first time, the presence of RET/PTC genes in follicular adenomas appeared after external irradiation.
|
9315093 |
1997 |