|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Regulatory factor X1 (RFX1) deletion has been reported to be correlated with poor prognosis of some types of cancer.
|
29764705 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Here we show reduced expression of the transcription factor RFX1 in CD4<sup>+</sup> T cells from patients with systemic lupus erythematosus, which leads to IL-17A overexpression through increased histone H3 acetylation and decreased DNA methylation and H3K9 tri-methylation.
|
29422534 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Regulatory factor X1 (RFX1) deletion has been reported to be correlated with poor prognosis of some types of cancer.
|
29764705 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
We concluded that I2 is required for virion morphogenesis, release of the D13 scaffold, and the association of EFC proteins with viral membranes.<b>IMPORTANCE</b> Poxviruses comprise a large family that infect vertebrates and invertebrates, cause disease in both in humans and in wild and domesticated animals, and are being engineered as vectors for vaccines and cancer therapy.
|
28490596 |
2017 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
We concluded that I2 is required for virion morphogenesis, release of the D13 scaffold, and the association of EFC proteins with viral membranes.<b>IMPORTANCE</b> Poxviruses comprise a large family that infect vertebrates and invertebrates, cause disease in both in humans and in wild and domesticated animals, and are being engineered as vectors for vaccines and cancer therapy.
|
28490596 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
However, the mechanisms that mediate reduction of RFX1 in SLE are unclear.
|
27283392 |
2016 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Since the RFX1 gene is often epigenetically silenced and clusters of differentiation (CD)44 proteins that regulate cancer cell biology are increased in human glioblastomas, we designed this study to determine whether RFX1 could regulate CD44 expression in glioblastoma.
|
24526308 |
2014 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Since the RFX1 gene is often epigenetically silenced and clusters of differentiation (CD)44 proteins that regulate cancer cell biology are increased in human glioblastomas, we designed this study to determine whether RFX1 could regulate CD44 expression in glioblastoma.
|
24526308 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
On the other hand, certain miRNAs, RFX1, defective ERK pathway signaling, Gadd45α and DNA hydroxymethylation have been proposed as potential mechanisms leading to DNA hypomethylation in lupus.
|
23340289 |
2013 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Because TGFβ is known to be involved in cancer development, our results provide initial evidence to suggest that RFX1 may play an important role in human tumor biology.
|
22582395 |
2012 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Because TGFβ is known to be involved in cancer development, our results provide initial evidence to suggest that RFX1 may play an important role in human tumor biology.
|
22582395 |
2012 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
By contrast, we find that Rfx1 expression in the esophageal epithelium becomes gradually extinguished during progression to cancer, i.e, expression of Rfx1 decreased markedly in dysplasia and adenocarcinoma.
|
21935353 |
2011 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
By contrast, we find that Rfx1 expression in the esophageal epithelium becomes gradually extinguished during progression to cancer, i.e, expression of Rfx1 decreased markedly in dysplasia and adenocarcinoma.
|
21935353 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.050 |
PosttranslationalModification
|
disease |
BEFREE |
In order to provide more insight into the epigenetic mechanisms leading to the deregulation of autoimmune-related genes in SLE, we asked whether RFX1 is involved in regulating histone 3 lysine 9 (H3K9) tri-methylation at the CD11a and CD70 promoters in SLE CD4(+) T cells.
|
21192791 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.050 |
Biomarker
|
disease |
BEFREE |
These findings reveal a crucial role for RFX1 in regulating the epigenetic status of T cells, and demonstrate that autoimmune responses in SLE are due in part to RFX1 downregulation.
|
20223637 |
2010 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Further survival analysis suggested that the downregulation of RFX1 correlated with poor prognosis and a high recurrence risk in HCC patients, particularly in small HCC patients.
|
29764705 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
The upstream transcription factor 1 (USF1), regulatory factor X-1 (RFX1), the Sp1 transcription factor 1 , POU class 3 homeobox 2 (POU3F2) and forkhead box L1 (FOXL1) regulatory transcription factor binding sites were identified in the IL-34 gene upstream (promoter) region, which may be involved in the effects of IL-34 in tumors.
|
25395235 |
2015 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Our study confirmed that RFX-1 acts as a tumor suppressor in HCC and might be a new target for HCC therapy.
|
25322871 |
2014 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
SC-2001, a molecule with similar structure to obatoclax, synergistically suppressed tumor growth when used in combination with sorafenib in vitro and overcame sorafenib resistance through up-regulating RFX-1 and SHP-1 resulting in tumor suppression and mediation of dephosphorylation of STAT3.
|
25047655 |
2014 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Importantly, SC-2001 suppressed tumor growth in association with enhanced RFX-1 and SHP-1 expression and p-STAT3 downregulation in MDA-MB-468 xenograft tumors.
|
24903225 |
2014 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our study confirmed that RFX-1 acts as a tumor suppressor in HCC and might be a new target for HCC therapy.
|
25322871 |
2014 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells.
|
24952874 |
2014 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma.
|
25047655 |
2014 |
|
Lupus Vulgaris
|
0.030 |
Biomarker
|
disease |
BEFREE |
On the other hand, certain miRNAs, RFX1, defective ERK pathway signaling, Gadd45α and DNA hydroxymethylation have been proposed as potential mechanisms leading to DNA hypomethylation in lupus.
|
23340289 |
2013 |
|
Lupus Erythematosus, Discoid
|
0.030 |
Biomarker
|
disease |
BEFREE |
On the other hand, certain miRNAs, RFX1, defective ERK pathway signaling, Gadd45α and DNA hydroxymethylation have been proposed as potential mechanisms leading to DNA hypomethylation in lupus.
|
23340289 |
2013 |