RFX1, regulatory factor X1, 5989

N. diseases: 47; N. variants: 0
Disease: Lupus Erythematosus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus 		0.030 Biomarker disease BEFREE On the other hand, certain miRNAs, RFX1, defective ERK pathway signaling, Gadd45α and DNA hydroxymethylation have been proposed as potential mechanisms leading to DNA hypomethylation in lupus. 23340289 2013
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus 		0.030 Biomarker disease BEFREE RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1. 21192791 2010
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus 		0.030 Biomarker disease BEFREE Reducing RFX1 in CD4(+) T cells is sufficient to cause lupus-like T and B cell hyperactivity, whereas overexpressing RFX1 suppresses T cell reactivity. 20223637 2010