|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We recommend using a geometric mean of the expression of CLTA, MRPL19 and ACTB for normalization of gene expression in melanomas and a geometric mean of the expression of CASC3 and RPS2 for normalization of gene expression in melanoma cell lines.
|
31567589 |
2020 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that PA and EPA change melanin content in melanoma to alter melanosome trafficking by modulating actin polymerization.
|
31345992 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased elasticity of melanoma cells after low-LET proton beam due to actin cytoskeleton rearrangements.
|
31065009 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest a critical link between cell morphology and cell signaling and reconcile the dichotomy of Rac1's regulation of both proliferation and actin assembly by revealing a mutual signaling axis wherein actin assembly drives proliferation in melanoma.
|
31063759 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This introduction triggers the tyrosyl-phosphorylation of ACTN4, a member of actin binding protein family involved in motility, a behavior critical for invasive progression, as shown by siRNA to Tyro3 limiting melanoma cell migration and invasion.
|
29274473 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipid rafts regulate the lamellipodia formation of melanoma A375 cells via actin cytoskeleton-mediated recruitment of β1 and β3 integrin.
|
30405793 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
All tumours exhibited positive findings for human melanoma black-45 and smooth muscle actin staining.
|
28122404 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ATII stimulation induced a decrease in MV3 cell migration and a more spherical cell morphology accompanied by an increase in the density of F-actin.
|
29558744 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the study was focused on the impact of the two lichen metabolites, on the viability (by Trypan blue test and fluoresceine diacetate and ethidium bromide assay), proliferation (cell counting in a Bürker's chamber), apoptosis (flow cytometry analysis and Western blot) and motile activity (cell movement recording and image analysis) and actin cytoskeleton organization (immunofluorescent staining) of melanoma HTB-140, prostate cancers DU-145 and PC-3, normal human skin fibroblasts and prostate epithelial PNT2 cells, with special emphasis to their selectivity and versatility.
|
28095330 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This interaction has important biological relevance since CDC42 and SCIN proteins have opposite effects in actin cytoskeleton organization and dynamics, a key mechanism underlying melanoma cell migration and invasion.
|
27347659 |
2016 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Forced NME1 expression in a variety of melanoma-derived cell lines was shown to induce dynamic changes in cell morphology and reorganization of the actin cytoskeleton, with formation of a network of thick stress fibers and assembly of fibronectin fibrils at large focal adhesions.
|
25017017 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Actinomyosin contraction, phosphorylation of VE-cadherin, and actin remodeling enable melanoma-induced endothelial cell-cell junction disassembly.
|
25225982 |
2014 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
α-Actinin-4 (ACTN4), a key regulator of the actin cytoskeleton, is up-regulated in melanoma, though its role in melanoma remains speculative.
|
25296750 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In melanoma and prostate cancer cells we have shown uPAR colocalization with β1/β3 integrins and actin cytoskeleton, as well integrins-actin co-localization under both mesenchymal and amoeboid conditions.
|
24681666 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Actin-binding protein, Espin: a novel metastatic regulator for melanoma.
|
24337068 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton.
|
24625986 |
2014 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Enforced miR-205 expression in melanoma cells profoundly impairs cell motility and migration along with significantly decreased F-actin polymerization with only a modest reduction in cell proliferation.
|
22525428 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
At the molecular level, we propose that Nck2 in human primary melanoma promotes the formation of molecular complexes regulating proliferation and actin cytoskeleton dynamics by modulating kinases or phosphatases activities that results in increased levels of proteins phosphorylated on tyrosine residues.
|
21992144 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Co-immunoprecipitation and bioluminescence resonance energy transfer (BRET) experiments indicate that hShrm1 and MCAM interact in vivo and by immunofluorescence microscopy some co-localization of these proteins is observed. hShrm1 partly co-localises with beta-actin and is found in the Triton X-100 insoluble fraction of melanoma cell extracts.
|
19137261 |
2009 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions.
|
19244113 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lumican affects actin cytoskeletal organization in human melanoma A375 cells.
|
18848571 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LAM has immunohistochemical expression of both smooth-muscle actin and a monoclonal antibody specific for human melanoma, HMB-45.
|
11564212 |
2001 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
All samples were positive for beta-actin and MART-1 and all but two were positive for tyrosinase, confirming RNA integrity and the presence of melanoma.
|
11397121 |
2001 |