Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the BCL6 gene and chromosome aberrations affecting 3q27 in 54 patients with non-Hodgkin's lymphoma.
|
9402330 |
1997 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving 3q27 that affect the BCL6 gene are common and specific chromosomal abnormalities in B-cell precursor non-Hodgkin lymphoma (mainly diffuse large-cell and follicular lymphoma), but they have not been reported in Burkitt lymphoma.
|
16772123 |
2006 |
Lymphoma, Non-Hodgkin
|
0.600 |
Biomarker
|
disease |
BEFREE |
LAZ3 is transcribed as a 3.8 kb message predominantly in normal adult skeletal muscle and in several NHL carrying 3q27 chromosomal defects.
|
8220427 |
1993 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Small deletions occur in highly conserved regions of the LAZ3/BCL6 major translocation cluster in one case of non-Hodgkin's lymphoma without 3q27 translocation.
|
9047392 |
1997 |
Lymphoma, Non-Hodgkin
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study suggests that BCL6 rearrangement is primarily associated with large cell lymphoma, and that BCL2(-)BCL6(+) NHL could potentially be curable with modern combination chemotherapy.
|
9209377 |
1997 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neither frequencies of the rare BCL6 allele 397C nor particular genotypes differed significantly between NHL cases and controls.
|
16125304 |
2006 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Using fluorescence in situ hybridization and molecular analyses, we report here on the rearrangement of the RhoH/TTF gene, at band 4p13, in four cases of NHL with t(3;4)(q27;p13) translocation and its fusion to the LAZ3/BCL6 gene at band 3q27, in three of these cases.
|
10803463 |
2000 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The gene was identified by fusion to the BCL6/LAZ3 oncogene in an initially described t(3;4)(q27;p11) translocation in a non-Hodgkin's lymphoma cell line.
|
9226377 |
1997 |
Lymphoma, Non-Hodgkin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Because H4 gene expression is tightly coupled to DNA replication, this study suggested an immediate mechanism for deregulated expression of BCL6, leading to the development of non-Hodgkin's lymphoma.
|
8988030 |
1997 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A new non-random chromosomal translocation t(3;6)(q27;p21.3) associated with BCL6 rearrangement in two patients with non-Hodgkin's lymphoma.
|
8923787 |
1996 |
Lymphoma, Non-Hodgkin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the tumor samples, expression of LAZ3/BCL6 was observed in 68% of all B cell NHL and none of the non-B lymphomas.
|
9096701 |
1997 |
Lymphoma, Non-Hodgkin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chromosomal translocation affecting the 3q27 band, where the BCL6 gene is localized, is one of the most common genetic abnormalities in non-Hodgkin's lymphoma of B-cell type (B-NHL).
|
15024721 |
2004 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In B cell lymphomas, structural alterations of the BCL-6 promoter region, including chromosome translocation and somatic hypermutation, represent the most frequent genetic lesions associated with non-Hodgkin lymphoma, especially of diffuse large cell lymphoma, a malignancy often derived from germinal centre (GC) B cells.
|
12469325 |
2002 |
Lymphoma, Non-Hodgkin
|
0.600 |
Biomarker
|
disease |
BEFREE |
PLZF is related to another POK protein, LAZ3(BCL6), which is structurally altered, and presumably misexpressed, in many non-Hodgkin lymphoma (NHL) cases.
|
11175338 |
2000 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, two other genes, BCL6 and BCL2, which are classically related to apoptosis and non-Hodgkin lymphoma, were shown for the first time to be involved in amplification.
|
15611930 |
2005 |
Lymphoma, Non-Hodgkin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Important in the development of HIV-associated NHL are cytokines and other factors that induce B-cell proliferation and increase the likelihood of mutations of c-myc, bcl-6, and other tumor-suppressor genes with carcinogenic potential.
|
9684278 |
1998 |
Lymphoma, Non-Hodgkin
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Rearrangements due to chromosomal translocations and somatic mutations of the 5' noncoding regulatory region of the BCL-6 gene are potential mechanisms for altering its expression in NHL.
|
10666217 |
2000 |
Lymphoma, Non-Hodgkin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Translocations of the BCL-6 gene to heterologous promoters and mutations of its 5'-noncoding regulatory region were reported to be potential mechanisms for deregulating BCL-6 expression and for playing a role in the genesis of non-Hodgkin lymphoma.
|
11290603 |
2001 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the BCL-6 gene in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma: association with diffuse large-cell subtype.
|
8025268 |
1994 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that biallelic DNA rearrangements and deletions would occasionally occur in NHL patients with BCL-6 abnormality.
|
7794763 |
1995 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results are compatible with previous cytogenetic reports in which the 3q27 translocation was observed in 15-20% of NHL; however, patients with the LAZ3 rearrangements exhibited a wide range of clinico-pathologic characteristics.
|
8063612 |
1994 |
Lymphoma, Non-Hodgkin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Chromosomal translocations and/or their molecular equivalents involving the BCL6 gene on 3q27 band have been suggested to be involved in the development of non-Hodgkin's lymphoma of B-cell type (B-NHL).
|
9747876 |
1998 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The t(2;3)(q21;q27) translocation in non-Hodgkin's lymphoma displays BCL6 mutations in the 5' regulatory region and chromosomal breakpoints distant from the gene.
|
9796700 |
1998 |
Lymphoma, Non-Hodgkin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The BCL6 gene mapped at chromosome band 3q27 encodes a zinc-finger transcription factor and is frequently rearranged and deregulated in B-cell non-Hodgkin's lymphoma (NHL) by promiscuous chromosomal translocations which involve diverse genes.
|
11579468 |
2001 |
Lymphoma, Non-Hodgkin
|
0.600 |
Biomarker
|
disease |
BEFREE |
The BCL-6 gene is involved in diffuse large-cell lymphoma and overexpressed in other types of non-Hodgkin's lymphoma and in high-grade breast cancer.
|
16331266 |
2006 |