|
Amaurosis congenita of Leber, type 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Following a broad panel of immunohistochemical stains, the strong positive staining of the spindle cells for LCA (CD45), CD20, and Bcl-6 confirmed the diagnosis of follicle center cell lymphoma.
|
31693188 |
2020 |
|
Bronchiolitis Obliterans
|
0.010 |
Biomarker
|
disease |
BEFREE |
A small-molecule BCL6 inhibitor reversed active cGVHD in a mouse model of multiorgan system injury with bronchiolitis obliterans associated with a robust GC reaction, but not in cGVHD mice with scleroderma as the prominent manifestation.
|
30279226 |
2019 |
|
Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A small-molecule BCL6 inhibitor reversed active cGVHD in a mouse model of multiorgan system injury with bronchiolitis obliterans associated with a robust GC reaction, but not in cGVHD mice with scleroderma as the prominent manifestation.
|
30279226 |
2019 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
We conclude that BCL6 attenuates proliferation and oxidative stress of VSMCs in hypertension.
|
30805081 |
2019 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection.
|
31138703 |
2019 |
|
Osteomyelitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to elucidate the NFATc1 and BCL6 mediated osteoclastic regulation and activity in MRONJ (BP) compared to osteoradionecrosis (ORN) and osteomyelitis (OM) and normal jaw bone.
|
30832685 |
2019 |
|
Polyarteritis Nodosa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that pan-cancer cells hijack this stress tolerance mechanism to aberrantly express BCL6.
|
30777872 |
2019 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast to the notion that BCL6 functions to suppress innate inflammation, we find that myeloid BCL6 deficiency diminished lung inflammation without affecting viral loads.
|
31138703 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
BCL6 inhibitor FX1 attenuates inflammatory responses in murine sepsis through strengthening BCL6 binding affinity to downstream target gene promoters.
|
31401377 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
BCL6 inhibitor FX1 attenuates inflammatory responses in murine sepsis through strengthening BCL6 binding affinity to downstream target gene promoters.
|
31401377 |
2019 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Applying the BioTarget tool to BCL6, a TF associated with germinal center lymphocytes, we observed that patients with an active BCL6 pathway had significantly improved survival for breast, colon, and stomach cancer.
|
31227749 |
2019 |
|
Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using germinal center B-cell-like diffuse large B-cell lymphoma (GC-DLBCL) and activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) cell lines, we analyzed the expression of MEF2B and its associations with BCL6, CD10, and ERK.
|
30446717 |
2019 |
|
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using a series of Cre-transgenic, reporter, and knockout mouse lines, we demonstrate that BCL6 deficiency in neutrophils, but not in monocytes or lung macrophages, attenuated host inflammation and morbidity following IAV infection.
|
31138703 |
2019 |
|
Complicated malaria
|
0.010 |
Biomarker
|
disease |
BEFREE |
PD-1 and BCL6 were increased in the SM group.
|
31614626 |
2019 |
|
Pneumonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast to the notion that BCL6 functions to suppress innate inflammation, we find that myeloid BCL6 deficiency diminished lung inflammation without affecting viral loads.
|
31138703 |
2019 |
|
POLYARTERITIS NODOSA, CHILDHOOD-ONSET
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that pan-cancer cells hijack this stress tolerance mechanism to aberrantly express BCL6.
|
30777872 |
2019 |
|
Double expressor lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among the 51 cases with MYC/BCL2 co-expression, 14 cases showed concurrence of MYC, BCL2 and/or BCL6 genetic abnormalities, and the remaining 37 cases were classified as double-expressor lymphoma (DEL).
|
31315646 |
2019 |
|
Miscarriage
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Women with suspected endometriosis and aberrant endometrial BCL6 expression have worse reproductive outcomes following embryo transfer, including a high miscarriage rate, poor IR, and low LBR and CPR compared to cycles pre-treated with medical and surgical management.
|
30610661 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
B‑cell CLL/lymphoma 6 member B (BCL6B), a BCL6‑homologous gene, has been reported to be a tumor suppressor that is silenced in a variety of human cancers, including colorectal cancer (CRC).
|
29393377 |
2018 |
|
Hepatitis A
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Low responsiveness to a hepatitis B virus vaccine in a Chinese population lacks association with ITGAL, CD58, TNFSF15, CCL15, TGFB3, and BCL6 gene variants.
|
29902581 |
2018 |
|
Hypothyroidism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The body mass-adjusted, steady-state maintenance dose of LT4 increased with GZMB and BCL6 levels in PB T cells of hypothyroid cases, mostly postmenopausal women having long-standing, non-goitrous and atrophic disease form.
|
29319368 |
2018 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity.
|
30566857 |
2018 |
|
Situs Inversus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we show that chronic simian immunodeficiency virus (SIV) infection is characterized by an expansion of either lymph node germinal center (GC) B cells that co-express Bcl6, Ki-67 and IL-21R and correlate with expanded T follicular helper (Tfh) cells or B cells that lack Bcl6, Ki-67 and IL-21R but express high levels of anti-apoptotic Bcl2 that negatively correlate with Tfh cells.
|
30191661 |
2018 |
|
Vascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The new data confirm BCL6 as a contributor to the sex-bias phenotype observed in hypoxic PAH in mice and support the neuroendocrine-STAT5-BCL6 hypothesis of sex bias in this experimental model of vascular disease.
|
30140283 |
2018 |
|
Allergic asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RORγt in T cells is required for optimal T<sub>H</sub>2 cell differentiation by suppressing Bcl6 expression; this finding suggests that targeting RORγt might be a promising approach for the treatment of allergic asthma by concomitantly suppressing T<sub>H</sub>17 and T<sub>H</sub>2 cell responses in the airway.
|
28943467 |
2018 |