|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chromosomal translocations (CTs) between immunoglobulin (Ig) genes and the BCL6 proto-oncogene are frequently associated with diffuse large B-cell lymphomas (DLBCLs) and follicular lymphomas (FLs) and are implicated in the development of these lymphomas.
|
16728698 |
2006 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To test the association of SHM with transformation of follicular lymphoma (FL), we sequenced mutational hot spots in five proto-oncogenes (BCL6, PAX5, RHOH, MYC and PIM1) in 32 low-grade FL (lgFL) with follicular histology and 26 transformed FL (tFL) with diffuse large cell histology.
|
18180034 |
2008 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
We present here a unique case of follicular lymphoma (FL) with rearranged BCL2, BCL6, and BCL1 (also known as CCND1) genes.
|
25953460 |
2015 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocation of BCL2 and BCL6 to the same immunoglobulin heavy chain locus in a case of follicular lymphoma.
|
16194898 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, CD10-MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1- typical FLs (67.0 versus 58.7 years, P < .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P < .001), diffuse proliferation (59% vs 19%, P < .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P < .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification).
|
17138820 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocations affecting BCL2 and BCL6 genes are rare in grade 3B follicular lymphomas (2/23, 9% and 4/23, 17%) when compared with grade 1 or 2 follicular lymphomas (22/25, 88%, P<0.001 and 0/25, P<0.05), FL/LCC (7/9, 78%, P<0.001 and 2/9, 22%), grade 3A follicular lymphomas (7/12, 58%, P<0.01 and 2/12, 17%), unclassified grade 3 follicular lymphomas (6/15, 40% and 2/15, 13%) and diffuse large B-cell lymphoma/follicular lymphoma grade 3B (2/16, 13% and 8/16, 50%, P<0.05).
|
21659362 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fluorescent in situ hybridization detected IGH/BCL2 translocation in 1 FL, increased BCL6 copy number in another FL, BCL6 rearrangement, and increased copy number of MYC and MALT1 in the DLBCL with marginal zone lymphoma.
|
28038709 |
2017 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No new mutations in the 5' noncoding regulatory region of the BCL-6 gene were detected in any of the specimens evaluated at the time of FCL relapse.
|
10887128 |
2000 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Bcl-6 mRNA and protein are frequently expressed in the transformed counterparts of the germinal center B-cells, diffuse large B-cell lymphoma and follicular lymphoma, irrespective of the gene rearrangements.
|
11353050 |
2001 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Bcl-6/CD10 coexpression was observed in 35 DLBCLs (34%) and 14 FLs (82%), and most of them showed a pattern of Bcl-6 expression similar to that of the GC.
|
11567225 |
2001 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymerase chain reaction (PCR), denaturing gradient gel electrophoresis (DGGE) and direct DNA sequencing were used to identify mutations in the 5' noncoding region of the BCL-6 gene in a total of 40 cases of diffuse large-cell lymphoma (DLCL) and follicular lymphoma (FL).
|
11780315 |
2001 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Numerous microRNAs were found to be differentially expressed between FL(BCL2+/BCL6+) and FL(BCL2-/BCL6+), as well as diffuse FL, when compared to typical cases of FL.
|
24778012 |
2014 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some of the genomic aberration acquired upon transformation, such as gain/amplification of 1q21-q24, 2p16 (REL/BCL11A gene loci), 3q27-q29 (including the BCL6 locus), 7q11.2-q22.1, 12pter-q12, 18q21 (including the BCL2 locus) and Xq, and deletion of 6q22-q24, 13q14-q21 and 17p13 (P53 locus) have been previously implicated in the FCL/DLBCL pathogenesis.
|
12406872 |
2003 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Integrative genomics and functional studies of BCL6 in primary FL cells point toward a novel mechanism whereby BCL6 repression of <i>NOTCH2</i> drives the survival and growth of FL cells as well as GC B cells, which are the FL cell of origin.<i>Cancer Discov; 7(5); 506-21.
|
28232365 |
2017 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the possible effect of this polymorphism on gene expression, BCL-6 mRNA levels in nine FCL tumors with the 397G-G genotype and in nine FCL tumors with the 397G-C genotype were measured by quantitative real-time RT-PCR.
|
11911418 |
2002 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
To characterize PCFL and PCMZL more clearly and to define criteria helpful for the differential diagnosis, we compared expression of immunohistochemical markers [LIM-only transcription factor 2 (LMO2), human germinal centre-associated lymphoma (HGAL), stathmin 1 (STMN1), activation-induced cytidine deaminase (AID), myeloid cell nuclear differentiation antigen (MNDA)] and the presence of cytogenetic abnormalities described previously in nodal follicular lymphoma [B cell lymphoma 2 (BCL2) and BCL6 breaks, 1p36 chromosomal region deletion (del 1p36)] in a series of 48 cutaneous follicular and marginal zone lymphomas [cutaneous follicular lymphoma (CFL) and cutaneous marginal zone lymphoma (CMZL)].
|
28594133 |
2017 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Follicle center lymphoma is associated with significantly elevated levels of BCL-6 expression among lymphoma subtypes, independent of chromosome 3q27 rearrangements.
|
12399978 |
2002 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mutations in the 5'-regulatory region of BCL6 were suggested to play a role in non-Hodgkin's lymphoma (NHL) progression and in the transformation of follicular lymphoma to more aggressive diffuse large B-cell type.
|
16125304 |
2006 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the role of the BCL-6 gene alterations in the histological transformation and clonal progression of FL, we analyzed serial biopsy specimens from 12 patients with FL.
|
10702417 |
2000 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, it has also been reported that FL lacks t(14;18), mainly among histological grade 3b, and occasionally has a rearranged Bcl-6 gene.
|
15723651 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis of DLCL and FL biopsy samples showed that the BCL-6 protein is detectable in these tumors independent of the presence of BCL-6 gene rearrangements.
|
7795255 |
1995 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
We studied the efficacy of 2 germinal center B-cell markers, HGAL and LMO2, in the separation of lymphomas derived from small B cells, particularly follicular lymphoma (FL) and marginal zone lymphoma occurring in nodal, extranodal, splenic, and bone marrow sites using immunohistochemical analysis for CD10, BCL6, BCL2, HGAL, and LMO2.
|
21502424 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent data suggest an alternative breakpoint cluster region (ABR) located between 245 and 285 kb 5' of BCL6, which might be associated with Follicular Lymphoma (FL).
|
16075463 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied a distinct cohort of FLs with a 3q27/BCL-6 gene rearrangement, but lacking the t(14;18) translocation.
|
12399977 |
2002 |
|
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In DLBCL and FL with t(14;18), the most common pattern of expression was bcl-2+/bcl-6+.
|
10414499 |
1999 |