Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis of DLCL and FL biopsy samples showed that the BCL-6 protein is detectable in these tumors independent of the presence of BCL-6 gene rearrangements.
|
7795255 |
1995 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
LAZ3 rearrangements were found in 10 DAL (28.6%), 9 TFL (17.3%), and 6 FL (14.3%), but not in any of the SNCL or MCL.
|
7742550 |
1995 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, the BCL6 gene is also altered by multiple (1.4 x 10(-3) -1.6 x 10(-2) per bp), often biallelic, mutations clustering in its 5' noncoding region.
|
8618933 |
1995 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Of the total of 32 BCL6(+) patients, six carried both BCL2 and BCL6 rearrangements; five of these six showed clinicopathological properties characteristic of follicular lymphoma, suggesting that the presence of the two genetic abnormalities does not necessarily have synergistic effects on malignant phenotypes.
|
8703825 |
1996 |
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The protein is also widely expressed in NHL: all follicular lymphomas tested showed a pattern of expression similar to the reactive B follicle, independently of the presence of BCL-6 gene rearrangement and/or 3q27 anomalies.
|
8758205 |
1996 |
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Rearrangement of BCL6 was observed in 6.4 to 14.3% of follicular lymphomas and 28.6 to 35.5% of diffuse large cell lymphomas; regarding the latter, a Japanese series showed a lower incidence.
|
9373196 |
1997 |
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Of the total of 32 BCL6(+) patients, 6 carried both BCL2 and BCL6 rearrangements, and showed clinicopathological properties of follicular lymphoma.
|
9209377 |
1997 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although rearrangement of the BCL6 gene is the most frequent genetic change among diffuse lymphomas and some follicular lymphomas this is the first report of a patient with MCL associated with BCL6 rearrangement.
|
9200999 |
1997 |
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bcl-6 abnormalities were mostly found in diffuse large cell lymphomas (29%) but also found in other subgroups, like FL (14%).
|
9573674 |
1998 |
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
To understand the functional consequence of the chromosomal translocations, we have studied the patterns of expression of the promoters found juxtaposed to BCL6 in DLCL and FL during B-lineage differentiation.
|
9427715 |
1998 |
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In DLBCL and FL with t(14;18), the most common pattern of expression was bcl-2+/bcl-6+.
|
10414499 |
1999 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Four cases of follicular lymphoma with t(14;18)(q32;q21) and t(3;4)(q27;p13) with LAZ3 (BCL6) rearrangement.
|
10347555 |
1999 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No new mutations in the 5' noncoding regulatory region of the BCL-6 gene were detected in any of the specimens evaluated at the time of FCL relapse.
|
10887128 |
2000 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the role of the BCL-6 gene alterations in the histological transformation and clonal progression of FL, we analyzed serial biopsy specimens from 12 patients with FL.
|
10702417 |
2000 |
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
All FL tested were bcl-6+ (19) and CD138- (22) with 16/19 also bcl-2 and CD10+ (classic phenotype), one bcl2+, CD10- (grade III) and two bcl2-, CD10+ (grade II or III).
|
11106080 |
2000 |
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
These mutations accumulating in the regulatory region of the BCL-6 gene could play a role in lymphoma progression and in the transformation of follicular lymphomas to more aggressive large cell lymphomas.(Blood.2000;95:1400-1405)
|
10666217 |
2000 |
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, Kostas Stamatopoulos and colleagues relate the molecular data about immunoglobulin genes and the protooncogenes BCL2 and BCL6 to the pathogenesis and evolution of follicular lymphoma.
|
10825742 |
2000 |
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Bcl-6 mRNA and protein are frequently expressed in the transformed counterparts of the germinal center B-cells, diffuse large B-cell lymphoma and follicular lymphoma, irrespective of the gene rearrangements.
|
11353050 |
2001 |
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Bcl-6/CD10 coexpression was observed in 35 DLBCLs (34%) and 14 FLs (82%), and most of them showed a pattern of Bcl-6 expression similar to that of the GC.
|
11567225 |
2001 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymerase chain reaction (PCR), denaturing gradient gel electrophoresis (DGGE) and direct DNA sequencing were used to identify mutations in the 5' noncoding region of the BCL-6 gene in a total of 40 cases of diffuse large-cell lymphoma (DLCL) and follicular lymphoma (FL).
|
11780315 |
2001 |
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the possible effect of this polymorphism on gene expression, BCL-6 mRNA levels in nine FCL tumors with the 397G-G genotype and in nine FCL tumors with the 397G-C genotype were measured by quantitative real-time RT-PCR.
|
11911418 |
2002 |
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Follicle center lymphoma is associated with significantly elevated levels of BCL-6 expression among lymphoma subtypes, independent of chromosome 3q27 rearrangements.
|
12399978 |
2002 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied a distinct cohort of FLs with a 3q27/BCL-6 gene rearrangement, but lacking the t(14;18) translocation.
|
12399977 |
2002 |
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We did not find significant differences in survival between patients with FL who showed exclusively bcl-6 mutations and those without bcl-6 mutations, but those patients with a high International Progostic Index score and p53 mutations showed the lowest overall survival (p = 0.002).
|
12217802 |
2002 |
Lymphoma, Follicular
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We correlated this with the immunohistochemical expression of CD10, bcl2 and bcl6, markers which are usually expressed by the neoplastic cells in follicular lymphomas.
|
12405909 |
2002 |