Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Double-hit lymphomas (DHLs) are collectively defined as B-cell non-Hodgkin lymphomas harboring rearrangements of MYC as well as B-cell lymphoma 2 (BCL2) and/or B-cell lymphoma 6 (BCL6).
|
26565895 |
2016 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
'Double-Hit' (DH) B cell non-Hodgkin lymphomas are characterized by the presence of a MYC rearrangement and additional rearrangement(s) most commonly involving BCL2 and/or BCL6.
|
24761809 |
2014 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The spectrum of B-cell non-Hodgkin lymphomas with dual IgH-BCL2 and BCL6 translocations.
|
18628087 |
2008 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BCL6 alternative breakpoint region break and homozygous deletion of 17q24 in the nodular lymphocyte predominance type of Hodgkin's lymphoma-derived cell line DEV.
|
16733207 |
2006 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, 2/9 cases showed 3q27 (BCL6) rearrangement, and 1/9 had p53 gene mutations, both of which are rarely detected in classical HL.
|
15982329 |
2005 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
These findings point to a critical role for BCL6 in the development of this distinct Hodgkin's lymphoma.
|
15339680 |
2004 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings point to a critical role for BCL6 in the development of this distinct Hodgkin's lymphoma.
|
15339680 |
2004 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of BCL-6 mutations in classic Hodgkin disease of the B- and T-cell type.
|
11290603 |
2001 |
Hodgkin Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Alterations on the 5' noncoding region of the BCL-6 gene are not correlated with BCL-6 protein expression in T cell non-Hodgkin lymphomas.
|
11742039 |
2001 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of chimaeric transcripts of the immunoglobulin heavy chain and BCL6 genes by reverse-transcriptase polymerase chain reaction in B-cell non-Hodgkin's lymphomas.
|
9504630 |
1998 |
Hodgkin Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression status of BCL-6 and syndecan-1 identifies distinct histogenetic subtypes of Hodgkin's disease.
|
9746758 |
1998 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data expand the spectrum of B-cell non-Hodgkin's lymphomas associated with BCL-6 5' mutations and have implications for the pathogenesis, histogenesis and clinical monitoring of Burkitt's lymphoma.
|
9359519 |
1997 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BCL-6 mutations occurred independent of BCL-6 rearrangements and presence of other genetic lesions frequently associated with AIDS-NHL.
|
9160681 |
1997 |
Hodgkin Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of LAZ3/BCL6 in follicular center (FC) B cells of reactive lymph nodes and FC-derived non-Hodgkin lymphomas.
|
9096701 |
1997 |
Hodgkin Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of BCL-6 among AIDS-NHLs occurred independently of the presence of molecular lesions of the bcl-6 gene.
|
9006332 |
1997 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The above immunohistological findings suggest that (a) bcl-6 may play a role in regulating B-cell differentiation step(s) occurring within germinal centers; (b) deregulated bcl-6 expression caused by rearrangements may contribute to B-lymphomagenesis; (c) bcl-6 is possibly involved in the pathogenesis of NLPHD.
|
9209651 |
1997 |
Hodgkin Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BCL-6 expression in reactive lymphoid tissue and in B-cell non-Hodgkin's lymphomas.
|
8758205 |
1996 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The LAZ3/BCL6 gene on chromosone 3q27 is recurrently disrupted in B cell non-Hodgkin's lymphomas by translocations involving immunoglobulin genes or other chromosone regions.
|
8618432 |
1996 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results further support the concept that NLPHD is an histogenetically distinct, B-cell-derived subtype of HD and suggest a role for BCL-6 in its development.
|
8555467 |
1996 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements and mutations of the LAZ3/BCL6 gene are the most frequent events associated with diffuse large-cell lymphoma, a particular class of non-Hodgkin's lymphomas.
|
9019154 |
1995 |
Hodgkin Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization identifies new chromosomal changes involving 3q27 in non-Hodgkin's lymphomas with BCL6/LAZ3 rearrangement.
|
8527378 |
1995 |
Hodgkin Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings confirm that BCL-6 is rearranged in a significant percentage of diffuse B-large cell lymphomas, suggesting that this proto-oncogene might have a pathogenetic role in this subset of NHLs, but our preliminary analysis suggests that BCL-6 lesions are not involved in the pathogenesis of HD.
|
7472775 |
1995 |
Hodgkin Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To assess the frequency and role of this gene's involvement in lymphomagenesis and tumor progression, we examined a series of 170 cases of non-Hodgkin's lymphomas of B-cell lineage for LAZ3 gene rearrangement, expression, and mutation.
|
7742550 |
1995 |