|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter's transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6.
|
31631728 |
2020 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most common scenario is transformation of follicular lymphoma to either diffuse large B-cell lymphoma or high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 translocations; however, other indolent subtypes such as marginal zone lymphoma, lymphoplasmacytic lymphoma, small lymphocytic lymphoma/chronic lymphocytic leukemia, or even nodular lymphocyte predominant Hodgkin lymphoma, can undergo similar histologic transformation.
|
30213394 |
2018 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified several unbalanced aberrations and a t(11;14) involving IGH and DDX6 providing evidence for a contribution of DDX6 to lymphomagenesis by deregulation of BCL6 in NMZL.
|
22965301 |
2013 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest Bcl6 as a marker for transformation of MALT lymphoma.
|
20830719 |
2011 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the efficacy of 2 germinal center B-cell markers, HGAL and LMO2, in the separation of lymphomas derived from small B cells, particularly follicular lymphoma (FL) and marginal zone lymphoma occurring in nodal, extranodal, splenic, and bone marrow sites using immunohistochemical analysis for CD10, BCL6, BCL2, HGAL, and LMO2.
|
21502424 |
2011 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Translocations involving IGH were detected in 36 (32%) of 111 cases; their partner genes included BCL6 (n = 10), c-MYC (n = 5), and FOXP1 (n = 3) but remained unknown in the remaining 18 cases. t(14;18)/IGH-BCL2, t(14;18)/IGH-MALT1, and t(1;14)/BCL10-IGH were not detected in any case. t(11;18)/API2-MALT1 was detected in none of the cases, except for one case of DLBCL with MALT lymphoma, which showed positive signals only in MALT lymphoma cells.
|
18445693 |
2008 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
With the exception of BCL6 protein expression in 2 of the 7 cases, these BCL6 translocation-positive MALT lymphomas were histologically and immunophenotypically identical to classic cases.
|
18166802 |
2008 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
With the exception of BCL6 protein expression in 2 of the 7 cases, these BCL6 translocation-positive MALT lymphomas were histologically and immunophenotypically identical to classic cases.
|
18166802 |
2008 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BCL6 translocation was detected in 5 (35%) of 14 DLBCL cases and in 1 (17%) of 6 MALT lymphoma cases (17%).
|
16484127 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We therefore analyzed six t(14;18)-positive MALT lymphomas (five parotid, one conjunctiva) by interphase fluorescence in situ hybridization for aneuploidies of chromosomes 3, 7, 12, 18, and X, gains or disruption of the CMYC/8q24 and BCL6/3q27 genes, as well as deletions of the retinoblastoma and TP53 tumor suppressor genes.
|
16364768 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Significantly, high BCL6 expression correlated strongly with longer overall survival (OS), independent of mechanism in gastric DLBCL and DLCLML.
|
16772602 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several balanced translocations have been identified in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) but there are few data regarding their frequency in different anatomic sites or the frequency of translocations involving BCL6 or kappa or lambda immunoglobulin light chain genes (IGK or IGL), particularly in patients from geographic regions other than Europe and Japan.
|
17122510 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Point mutations in the 5' noncoding region of BCL-6 gene are found in Chinese patients with primary gastric DLBCLs and MALT lymphomas, suggesting that they may, in some extent, participate in the pathogenesis of primary gastric DLBCLs and MALT lymphomas.
|
15609396 |
2005 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Point mutations in the 5' noncoding region of BCL-6 gene are found in Chinese patients with primary gastric DLBCLs and MALT lymphomas, suggesting that they may, in some extent, participate in the pathogenesis of primary gastric DLBCLs and MALT lymphomas.
|
15609396 |
2005 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BCL-6 mutations in pulmonary MALT lymphoma and HIV-negative LIP showed some features (high transition to transversion ratio, standard polarity, and RGYW/WRCY bias) of Ig V(H) gene hypermutation, leading to the view that pulmonary MALT lymphomas and HIV-negative LIP are under the influence of germinal center hypermutation mechanisms.
|
15153535 |
2004 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MALT lymphoma is a tumor of a post-germinal center (GC) memory B-cell origin, which is negative for Bcl-6 protein expression in low-grade but may become positive in high-grade tumors.
|
12766583 |
2003 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Bcl-6 mutations were observed in 11 of 13 (84.6%) low-grade gastric lymphomas of the MALT type and in 8 of 12 (66.7%) diffuse large B-cell gastric lymphomas.
|
11353050 |
2001 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We suggest that mutations of BCL6 and BCL10 genes are rare in low-grade MALT lymphoma of ocular adnexa and are unlikely to be involved in the pathogenesis of the disease.
|
11120333 |
2000 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutation of the 5' noncoding region of the BCL-6 gene in low-grade gastric lymphoma of the mucosa-associated lymphoid tissue.
|
9546062 |
1998 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conversely, rearrangements of BCL-6 and mutations of p53 clustered with a fraction of high-grade MALT-lymphomas.
|
9395180 |
1997 |