|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The association is either a chance occurrence or due to the induction of lymphoma cell proliferation by the binding of FSH produced by the adenoma to the FSH receptors on the lymphoma cells.
|
28362886 |
2017 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
LHb and FSHb genes showed the highest expression, respectively, in LH-producing and FSH-producing pituitary adenomas; however, our analysis did not show statistically significant differences between LH-producing and FSH-producing adenomas.
|
26884293 |
2016 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The methylation status of the p18(INK4C) gene promoter and somatic mutations of the p18(INK4C) gene were also investigated. p18(INK4C) protein expression was lost or significantly reduced in 64% of pituitary adenomas compared with levels in normal pituitary glands. p18(INK4C) mRNA levels were low in all ACTH adenomas and non-functioning (NF)-FSH and in 42%, 70% and 66% of GH, PRL, and subtype 3 adenomas, respectively. p18(INK4C) mRNA levels were significantly associated with p18(INK4C) protein levels.
|
19401813 |
2009 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
OHSS may result not from increased FSH levels, but also from increased bioactivity of the FSH derived from the adenoma.
|
18056718 |
2008 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The signals for hormone production were detected in both adenoma types in a range from 42% for GH in oncocytomas to 78% for beta-FSH in null cell adenomas.
|
11700887 |
2001 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In vitro leptin stimulation of pituitary tumours caused stimulation of FSH and alpha-subunit secretion from a non-functioning adenoma and TSH secretion from a somatotroph adenoma.
|
11422113 |
2001 |
|
Adenoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ISH detected signals for all pituitary hormones at a range of 30% for prolactin (PRL) to 85% for proopiomelanocortin (POMC). mRNA for beta-FSH was detected in 70% and beta-LH mRNA in 43% of adenomas.
|
11579683 |
2001 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We studied a total of 107 pituitaries, including normal pituitary (n = 20), Cushing's disease (n = 21), acromegaly (n = 19), nonfunctioning adenomas (n = 18), prolactinomas (n = 7), TSH-omas (n = 2), FSH-omas (n = 6), aggressive tumors showing invasiveness and recurrence (n = 9), and metastatic pituitary carcinomas (n = 5).
|
10523037 |
1999 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In all cases, immunocytochemical studies of the removed adenoma confirmed their gonadotroph nature by revealing positivity for FSH, LH and/or alpha-subunit.
|
9724070 |
1998 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, our sample contains 8 FSH and LH adenomas.
|
9398737 |
1997 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Gonadotroph (LH/FSH) and null cell adenomas had significantly higher levels of particulate, soluble, and total PKC activity compared with growth hormone (GH) adenomas (P < 0.05).
|
8434650 |
1993 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Most null cell adenomas and the oncocytoma secreted FSH and LH into the culture medium.
|
7680355 |
1993 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, ACTH- and LH-FSH-secreting and non-secreting adenomas were negative.
|
8297469 |
1993 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We studied the effects of GnRH, CRF, dexamethasone, and phorbol 12-myristate 13-acetate on FSH and LH secretion and on FSH beta and chromogranin-A and -B mRNA expression in 10 chromogranin-A-positive adenomas in vitro to analyze the regulation of FSH and chromogranin-A and -B expression in these neoplasms.
|
2118538 |
1990 |