|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations:</b> AR: androgen receptor; FSH: follicle stimulating hormone; Gn: gonadotropins; GnRH: gonadotropin-releasing hormone; hCG: human chronic gonadotropin; HH: hypogonadotropic hypogonadism; LH: luteinizing hormone; PCR: polymerase chain reaction.
|
31030566 |
2019 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The established clinical indication for FSH use in male infertility is the treatment of patients with hypogonadotropic hypogonadism for stimulation of spermatogenesis that allows the induction of a clinical pregnancy in the female partner and finally the birth of a healthy child.
|
31178827 |
2019 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, FSH was inversely associated with sRANKL in both infertile men and KS men (p = .023 and p = .012).
|
30914274 |
2019 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
If puberty has not started by age 14 years, monitoring of serum concentrations of LH, FSH, testosterone, and inhibin B to evaluate for the possibility of HH is necessary.
|
29361664 |
2018 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association of recombinant FSH plus recombinant LH in 2:1 ratio may be used not only to induce ovulation in anovulatory women with hypogonadotropic hypogonadism but also to achieve multiple follicular developments in human IVF.
|
30021630 |
2018 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recombinant human FSH administration improves sperm DNA integrity in hypogonadotropic hypogonadism and idiopathic oligoasthenoteratozoospermia men with DNA fragmentation index value >15 % .
|
23435529 |
2013 |
|
Klinefelter Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The patient showed the classic phenotype of Klinefelter syndrome but with low levels of FSH and LH.
|
21703612 |
2011 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The etiology of HHG involves a combined and variable deficiency of hypothalamic GnRH secretion and/or pituitary responsiveness to GnRH resulting in low LH, FSH and testosterone.
|
21672607 |
2011 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Endocrine biochemistry at presentation showed hypogonadotropic hypogonadism (LH 2.4 U/L, FSH <1.0 IU/L, testosterone 2.8 nmol/L) with increased serum estrone (E(1), 821 pmol/L) and estradiol (E(2), 797 pmol/L) and subclinical ACTH-independent hypercortisolism (serum cortisol post 1mg overnight dexamethasone suppression test, 291 nmol/L).
|
20467160 |
2010 |
|
Klinefelter Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings and decreased plasma LH and FSH levels at age 19 years were compatible with hypogonadotropic hypogonadism.
|
18449926 |
2008 |
|
Klinefelter Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum FSH levels were elevated (21.7 IU/l) compared to normal age-matched healthy male controls and patients with non-mosaic Klinefelter syndrome, and inhibin B levels were low-normal, in contrast to the usually undetectable inhibin B levels in adult Klinefelter patients.
|
17554105 |
2007 |
|
Klinefelter Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Despite normal T concentrations, the KS boys displayed from the age of 13 y elevated serum FSH and LH levels, and exaggerated gonadotropin responses to gonadotropin-releasing hormone.
|
16641204 |
2006 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Basal luteinizing hormone and FSH, testosterone, or estradiol levels were measured in 37 healthy subjects (21 women) and in 27 hypogonadotropic hypogonadism patients (13 women) by immunofluorometric methods (hLH-Spec and hFSH-Spec, AutoDELFIA, Wallac Oy, Turku, Finland).
|
16358135 |
2005 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The postnatal surge in FSH, LH, and testosterone in the male infant as a consequence of the continued function of the fetal GnRH pulse generator provides a 6-month window of opportunity to establish the diagnosis of hypogonadotropic hypogonadism and alert the clinician to the possibility of its association with multiple pituitary hormone deficiencies.
|
15728198 |
2005 |
|
Klinefelter Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Endocrine studies showed normal adrenal function (cortisol response to ACTH stimulation, 13.4-->25.3 microg/dl) and primary hypogonadism (testosterone response to hCG stimulation, 0.57-->0.76 ng/ml; gonadotropin responses to GnRH stimulation: LH, 10-->59 mIU/ml; FSH, 36-->69 mIU/ml), and urinary steroid hormone profile analysis indicated grossly normal steroidogenic enzyme activities.
|
15579739 |
2004 |
|
Klinefelter Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
When non-KS oligo-azoospermic patients were classified according to histology [Sertoli cell-only (SCO), n = 18 or non-Sertoli cell only (non-SCO), n= 18] and compared to KS patients, the hormonal pattern did not differ between SCO and non-SCO subjects, but levels in KS patients were significantly different for FSH, inhibin-B and the FSH/inhibin-B ratio.
|
12864799 |
2003 |
|
Klinefelter Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum LH, FSH and testosterone levels were low, indicating hypogonadotropic hypogonadism.
|
12402986 |
2002 |
|
Klinefelter Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The patient had a growth spurt, bone maturation, progression of genital and pubic hair stages, and normalization of plasma T level (15.8 nmol/L) after a 12-month treatment with twice weekly injections of hCG and human menopausal gonadotropin (75 IU International Reference Preparation 2) preparations, suggesting that, in presence of FSH, a Sertoli cell-secreted factor stimulated Leydig cell production of T. In conclusion, we report a novel mutation in the DAX-1 gene in patients with AHC and HH.
|
10522996 |
1999 |
|
Klinefelter Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Plasma LH and FSH levels were abnormally high and testosterone levels were reduced in all the patients with Klinefelter's syndrome.
|
10202890 |
1999 |
|
Klinefelter Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Primary hypogonadism was documented by finding low serum testosterone and raised serum LH and FSH levels.
|
568665 |
1978 |
|
Klinefelter Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These studies show that elevated levels of LH and FSH in primary hypogonadism syndrome may not become apparent until after the onset of CNS puberty.
|
342383 |
1978 |
|
Klinefelter Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Chromatin-positive Klinefelter's syndrome with undetectable peripheral FSH levels.
|
1166860 |
1975 |