|
Malignant neoplasm of liver
|
0.220 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that depletion of both PTEN and SAV1 in liver promotes spontaneous NAFLD and liver cancer through hyperactive AKT via YAP/TAZmediated up-regulation of IRS2 transcription.
|
29699606 |
2018 |
|
Malignant neoplasm of liver
|
0.220 |
Biomarker
|
disease |
BEFREE |
Here, we have shown that deletion of both PTEN and SAV1 in the liver accelerates the development of NAFLD and liver cancer in mice.
|
29400692 |
2018 |
|
Malignant neoplasm of liver
|
0.220 |
Biomarker
|
disease |
MGD |
|
|
|
|
Liver carcinoma
|
0.210 |
GeneticVariation
|
disease |
BEFREE |
Forty-one CCGs appeared specific for NAFLD-HCC, including Sav1, a component of the Hippo signaling pathway and the most frequently mutated gene identified in both NAFLD-HCC screens.
|
30327349 |
2018 |
|
Liver carcinoma
|
0.210 |
Biomarker
|
disease |
MGD |
|
|
|
|
Colonic Diseases
|
0.200 |
Biomarker
|
group |
MGD |
|
|
|
|
Liver neoplasms
|
0.200 |
Biomarker
|
group |
MGD |
|
|
|
|
Hepatoblastoma
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Hepatoblastoma Caused By Somatic Mutation
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Platelet mean volume determination (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Additionally, the tumorigenesis of SW480 cells in xenografted mice was significantly inhibited by SAV1 overexpression but promoted by SAV1 knockdown.
|
30681889 |
2019 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Moreover, treatment with the AKT inhibitor MK-2206 or knockout of IRS2 by AAV-Cas9 successfully repressed liver tumorigenesis in Pten-/- Sav1-/- mice.
|
29400692 |
2018 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, SAV1 worked as a cancer suppressor and it might be considered as a target for pancreatic cancer therapy.
|
28968962 |
2017 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
SAV1 participates in the development of diverse types of cancer.
|
28618450 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
SAV1 participates in the development of diverse types of cancer.
|
28618450 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, SAV1 worked as a cancer suppressor and it might be considered as a target for pancreatic cancer therapy.
|
28968962 |
2017 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, over-expression of WW45 inhibited the tumorigenesis in a de novo lung cancer tumorigenesis mouse model (LKB-Ras) as well as the expression of Gli1.
|
27661123 |
2016 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
However, how the negative regulation induced by MST1-SAV1 complex is disrupted to exhibit constitutive YAP/TAZ activation in cancer remains unclear.
|
26241672 |
2015 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
However, how the negative regulation induced by MST1-SAV1 complex is disrupted to exhibit constitutive YAP/TAZ activation in cancer remains unclear.
|
26241672 |
2015 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In our study, we analyzed the role of RASSF2, RASSF3, RASSF4, RASSF5A, RASSF5C and RASSF6 and the effectors MST1, MST2 and WW45 in thyroid carcinogenesis.
|
20920251 |
2010 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
It was also reported that human salvador (hWW45) is mutated in some cancer cell lines.
|
12969014 |
2003 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
It was also reported that human salvador (hWW45) is mutated in some cancer cell lines.
|
12969014 |
2003 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MiR-21 levels significantly and negatively correlated with SAV1 expression in CRC tissues.
|
30681889 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In conclusion, SAV1 suppresses tumor growth in CRC and is regulated by miR-21.
|
30681889 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we have shown that deletion of both PTEN and SAV1 in the liver accelerates the development of NAFLD and liver cancer in mice.
|
29400692 |
2018 |