RNF6, ring finger protein 6, 6049

N. diseases: 46; N. variants: 4
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE Taken together, these results demonstrate that RNF6 plays a pivotal oncogenic role in colorectal tumorigenesis.<b>Significance:</b> RNF6-mediated ubiquitination and degradation of TLE3 activates the Wnt/β-catenin pathway in colorectal carcinogenesis.<i>Cancer Res; 78(8); 1958-71.©2018 AACR</i>. 29374067 2018