Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations of the ELAC2 gene have been found to confer increased prostate cancer susceptibility in families.
|
31452838 |
2019 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One rare missense variant associated with the occurrence of prostate cancer (p.Arg781His) impairs the mitochondrial RNase Z activity of ELAC2, suggesting a functional link between tumorigenesis and mitochondrial RNA metabolism.
|
31045291 |
2019 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In our study, we investigated the potential association between KLK3, AR, RNASEL, MSR1, and ELAC2 polymorphisms, expression patterns, exposure to environmental factors, and PCa in a Spanish cohort.
|
27318894 |
2016 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study provides the proof-of-principle that some of the genetic variants (such as rs486907, rs627928 and rs2127565) in genes RNASEL, MSR1 and ELAC2 can be used as predictors of aggressiveness and progression of PCa.
|
26251261 |
2015 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations.
|
23141781 |
2013 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HPC/ELAC-2 is considered as an important cancer-susceptibility gene in prostate cancer.
|
20119870 |
2011 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A survey of green plant tRNA 3'-end processing enzyme tRNase Zs, homologs of the candidate prostate cancer susceptibility protein ELAC2.
|
21781332 |
2011 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis showed evidence that ELAC2 Ser217Leu and Ala541Thr polymorphisms were associated with prostate cancer risk, and might be low-penetrance susceptibility markers of prostate cancer.
|
20231859 |
2010 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combining high-risk genotypes of MSR1 and ELAC2 in Caucasians and of RNASEL and MSR1 in Hispanics showed synergistic effects and suggest that an interaction between both genes in each ethnicity is likely to confer prostate cancer risk.
|
20086112 |
2010 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification and analysis of candidate fungal tRNA 3'-end processing endonucleases tRNase Zs, homologs of the putative prostate cancer susceptibility protein ELAC2.
|
20819227 |
2010 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We genotyped eight tagging SNPs in ELAC2 to test for the association between sequence variances in ELAC2 and prostate cancer.
|
18375959 |
2008 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HPC2/ELAC2 217L allele was significantly associated with risk of prostate cancer when taking all cases into account (OR = 1.6; 1.0-2.6; P = 0.03).
|
18767027 |
2008 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined polymorphisms within ELAC2 (S217L, A541T, E622V), MSR1 (P275A, R293X, aIVS5-59c), and RNASEL (E265X, R462Q, D541E) in 150 European-Americans with metastatic prostate cancer and 170 prostate cancer-free controls using pyrosequencing assays.
|
16114055 |
2006 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we found that the candidate prostate cancer susceptibility gene ELAC2 potentiates TGF-beta/Smad-induced transcriptional responses.
|
16636667 |
2006 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The missense mutations in the candidate prostate cancer gene ELAC2 do not alter enzymatic properties of its product.
|
15863270 |
2005 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of linkage disequilibrium structure, mutation history, and tagging SNPs, and their use in association analyses: ELAC2 and familial early-onset prostate cancer.
|
15593091 |
2005 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide genetic evidence that prostate cancer susceptibility gene ELAC2 may be involved in RNA processing, especially rRNA processing and mitochondrial function.
|
15892892 |
2005 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Early linkage results have provided targeted candidate regions for prostate cancer susceptibility loci, including HPC1 on chromosome 1q23-25, PCAP on chromosome 1q42-43, CAPB on chromosome 1p36, linkage to chromosome 8p22-23, HPC2 on chromosome 17p, HPC20 on chromosome 20q13, and HPCX on chromosome Xq27-28.
|
14749351 |
2004 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HPC2/ELAC2 polymorphism associated with Japanese sporadic prostate cancer.
|
15368467 |
2004 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed 39 clinical prostate cancer specimens, 10 prostate cancer xenografts (LuCaP series), and 4 prostate cancer cell lines (LNCaP, DU145, PC-3, and MPC-3) for genetic changes using denaturing high-performance liquid chromatography and direct sequencing in order to screen the whole coding regions of RNASEL and MSR1, as well as exons 7 and 17 of ELAC2.
|
14695991 |
2004 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2.
|
15358515 |
2004 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine the contribution of two HPC2/ELAC2 missense variants (Ser217Leu and Ala541Thr) to the risk of developing prostate cancer, we conducted a population-based case-control study of middle-aged men (40-64 years).
|
14504198 |
2003 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BLAST search of them suggested that the enzyme was the product of a candidate human prostate cancer susceptibility gene, ELAC2, the biological function of which was totally unknown.
|
12711671 |
2003 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, our linkage results suggest that there is a prostate cancer susceptibility gene on chromosome 17 that is independent of ELAC2.
|
14601029 |
2003 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study suggested that the common variants in the HPC2/ELAC2 gene play a limited role in the risk of prostate cancer in the Japanese population.
|
12552947 |
2003 |