|
Prostate cancer, familial
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Germline genetic profiling in prostate cancer: latest developments and potential clinical applications.
|
28031937 |
2016 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations.
|
23141781 |
2013 |
|
Prostate cancer, familial
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations.
|
23141781 |
2013 |
|
Prostate cancer, familial
|
0.600 |
Biomarker
|
disease |
BEFREE |
The RNASEL and HPC2/ELAC2 genes have been implicated in hereditary prostate cancer.
|
18767027 |
2008 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These include the ELAC2 (HPC2), MSR1, and RNASEL (HPC1) genes that have germline mutations in familial prostate cancer; AR, ATBF1, EPHB2 (ERK), KLF6, mitochondria DNA, p53, PTEN, and RAS that have somatic mutations in sporadic prostate cancer; AR, BRCA1, BRCA2, CHEK2 (RAD53), CYP17, CYP1B1, CYP3A4, GSTM1, GSTP1, GSTT1, PON1, SRD5A2, and VDR that have germline genetic variants associated with either hereditary and/or sporadic prostate cancer; and ANXA7 (ANX7), KLF5, NKX3-1 (NKX3.1), CDKN1B (p27), and MYC that have genomic copy number changes affecting gene function.
|
16267836 |
2006 |
|
Prostate cancer, familial
|
0.600 |
Biomarker
|
disease |
BEFREE |
To date, germline mutations have been found in three candidate genes for hereditary prostate cancer: ELAC2 at 17p11, RNASEL at 1q25 and MSR1 at 8p22.
|
15714208 |
2005 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that Thr allele at 541 in HPC2/ELAC2 has strong significance in the predisposition of sporadic Pca in Japan.
|
15368467 |
2004 |
|
Prostate cancer, familial
|
0.600 |
Biomarker
|
disease |
BEFREE |
The HPC2/ELAC2 gene on chromosome 17p11 was identified as a candidate gene for hereditary prostate cancer (HPC) susceptibility.
|
14625808 |
2003 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
An epidemiological study was done in sporadic PCa (n=98) and BPH (n=143) using 1 novel (Ser627Leu) and 2 previously described polymorphisms of the HPC2/ELAC2 gene.
|
12949798 |
2003 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterozygosity of the putative prostate cancer susceptibility gene HPC2/ELAC2 is uncommon in sporadic and familial prostate cancer.
|
11751379 |
2001 |
|
Prostate cancer, familial
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the relationship between HPC2/ELAC2 and prostate cancer risk, we performed the following analyses: (1) a linkage study of six markers in and around the HPC2/ELAC2 gene at 17p11 in 159 pedigrees with hereditary prostate cancer (HPC); (2) a mutation-screening analysis of all coding exons of the gene in 93 probands with HPC; (3) family-based and population-based association study of common HPC2/ELAC2 missense variants in 159 probands with HPC, 249 patients with sporadic prostate cancer, and 222 unaffected male control subjects.
|
11254448 |
2001 |
|
Prostate cancer, familial
|
0.600 |
Biomarker
|
disease |
BEFREE |
Role of HPC2/ELAC2 in hereditary prostate cancer.
|
11522646 |
2001 |