Liver diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Intrahepatic mRNA expression of interferon-inducible antiviral genes in liver diseases: dsRNA-dependent protein kinase overexpression and RNase L inhibitor suppression in chronic hepatitis C.
|
11050060 |
2000 |
Hepatitis C, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Also, the expression of the RNase L inhibitor showed a significant reduction in chronic hepatitis C (P =.0184).
|
11050060 |
2000 |
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients.
|
15809757 |
2005 |
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that the ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients.
|
15809757 |
2005 |
Colonic Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients.
|
15809757 |
2005 |
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that the ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients.
|
15809757 |
2005 |
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The genes functions were related to a diverse cellular process including: (1) most of these genes were associated with CD4+ T cells functions, particularly related to cellular developments; (2) Ras pathway genes as RANBP10, GMIP, RASGRP2 and ARL5 might be responsible for the abnormal development of CD4+ T cells of SLE; (3) HIG2, TCF7, KHSRP, WWP1, SMAD3, TLK2, AES, CCNI and PIM2 belong to Wnt/beta-catenin way, they could play roles in modulating proliferation and differentiation of T lymphocytes; (4) uncertain viral infections may initiate autoimmunity because high levels expression genes were detected in T4-1s such as TRIM22, IER2, ABCE1, DUT, G1P2, G1P3, HNRPUL1, EVER2, IFNAR1, TNFSF14, TMP21 and PVRL2; and (5) apoptosis relating genes as EIF3S8, SH3BGRL3, GPX4, TOSO, PFDN5, BIN1, XIAPAF1, TEGT and CUGBP2 may contribute to over uploading of selfantigens in SLE cells.
|
16143398 |
2006 |
Prostatic Neoplasms
|
0.010 |
GeneticVariation
|
group |
LHGDN |
RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.
|
18189233 |
2008 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Taken together, our findings show that fasudil prevents cancer metastasis by inhibiting the Rho/Rho kinase pathway and that the ABCE1 gene was involved in the migration of 95-D cells.
|
19879105 |
2010 |
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Taken together, our findings show that fasudil prevents cancer metastasis by inhibiting the Rho/Rho kinase pathway and that the ABCE1 gene was involved in the migration of 95-D cells.
|
19879105 |
2010 |
Small cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
ABCE1 may be used as a potential target of gene therapy for small cell lung cancer in future.
|
20372810 |
2010 |
Colorectal Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
The role of ABC transporters in progression and clinical outcome of colorectal cancer.
|
22294766 |
2012 |
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
The role of ABC transporters in progression and clinical outcome of colorectal cancer.
|
22294766 |
2012 |
Adenocarcinoma of lung (disorder)
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results demonstrated the potential role of ABCE1 in human lung adenocarcinoma, which may provide some molecular basis for the mechanisms of development and progress of human lung adenocarcinoma, and help to find new pharmacological targets.
|
22267055 |
2012 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Studies in lung cancer have shown that overexpression of ABCE1 in tumor cells promotes growth and inhibits apoptosis.
|
25070080 |
2014 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Studies in lung cancer have shown that overexpression of ABCE1 in tumor cells promotes growth and inhibits apoptosis.
|
25070080 |
2014 |
Primary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Studies in lung cancer have shown that overexpression of ABCE1 in tumor cells promotes growth and inhibits apoptosis.
|
25070080 |
2014 |
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, ABCE1‑siRNA was found to inhibit proliferation and invasion in breast cancer cells, significantly induce breast cancer cell apoptosis (P<0.05) in vitro and increase the protein expression of RNase L. These findings showed that ABCE1 had an important role in proliferation, invasion and apoptosis in MCF‑7 human breast cancer cells and that ABCE1 may inhibit intracellular RNase L activity, which inhibits the 2‑5A/RNase L pathway, interfering with the biological characteristics of breast cancer cells.
|
25070080 |
2014 |
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, ABCE1‑siRNA was found to inhibit proliferation and invasion in breast cancer cells, significantly induce breast cancer cell apoptosis (P<0.05) in vitro and increase the protein expression of RNase L. These findings showed that ABCE1 had an important role in proliferation, invasion and apoptosis in MCF‑7 human breast cancer cells and that ABCE1 may inhibit intracellular RNase L activity, which inhibits the 2‑5A/RNase L pathway, interfering with the biological characteristics of breast cancer cells.
|
25070080 |
2014 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, ABCE1‑siRNA was found to inhibit proliferation and invasion in breast cancer cells, significantly induce breast cancer cell apoptosis (P<0.05) in vitro and increase the protein expression of RNase L. These findings showed that ABCE1 had an important role in proliferation, invasion and apoptosis in MCF‑7 human breast cancer cells and that ABCE1 may inhibit intracellular RNase L activity, which inhibits the 2‑5A/RNase L pathway, interfering with the biological characteristics of breast cancer cells.
|
25070080 |
2014 |
Esophageal carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
ABCE1 expression is low in the adjacent non-tumor tissues while the expression is high in the esophageal carcinoma; the expression is reversely proportional to the differentiation degrees.
|
24551278 |
2014 |
Malignant neoplasm of esophagus
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study aims to explore the clinical characteristics of ABCE1 in esophageal cancers and its roles in the proliferation, invasiveness, migration and apoptosis of the esophageal carcinoma Eca109 cell line.
|
24551278 |
2014 |
Malignant neoplasm of mouth
|
0.010 |
Biomarker
|
group |
BEFREE |
ABCE1 is closely connected with the pathogenesis and development of oral cancer, which acts through the cellular pathways of 2-5A/RNase L.
|
25337191 |
2014 |
Lip and Oral Cavity Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ABCE1 is closely connected with the pathogenesis and development of oral cancer, which acts through the cellular pathways of 2-5A/RNase L.
|
25337191 |
2014 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
This work aimed to investigate the alterations in chemosensitivity of A549 lung cancer cells for 5-Fluorouracil (5-FU) and irinotecan by silencing ABCE1 using specific small interfering RNAs (siRNA).
|
25744244 |
2015 |