|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of CCL7 and ABCE1 in lung cancer tissues obtained from 30 patients with non-small cell lung cancer (NSCLC) was higher than that in adjacent normal lung tissues (P<0.01), and a positive correlation between the expression levels of the two genes in NSCLC was observed.
|
30214518 |
2018 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our study suggested ABCE1 as a promising target for glioma chemotherapy.
|
30455394 |
2018 |
|
Thymic Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ABCE1 and CLIC2 are promising to be diagnostic candidate biomarkers in thymic carcinomas (TCs).
|
29645059 |
2018 |
|
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genistein suppresses retinoblastoma cell viability and growth and induces apoptosis by upregulating miR-145 and inhibiting its target ABCE1.
|
28706438 |
2017 |
|
Lung Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In summary, we have provided evidence that ABCE1 plays an essential role in the progression and metastasis of lung cancers and may represent a valuable therapeutic target for the management of lung tumor.
|
26733164 |
2016 |
|
Secondary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of ABCE1 is correlated with aggressive growth and metastasis in lung cancer cells.
|
27109616 |
2016 |
|
Malignant neoplasm of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
We designed and synthesized targeted ABCE1-siRNA sequences and a negative control sequence (NC-siRNA), and transfected them into human thyroid cancer SW579 cells by electrotransfer to obtain ABCE1-SW579 and NC-siRNA-SW579 cells (siRNA is small interfering RNA).
|
26600528 |
2015 |
|
Esophageal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results revealed that ABCE1 is closely associated with cell proliferation, invasion and migration in esophageal cancer and silencing the ABCE1 gene by electroporation can significantly reduce the proliferation, invasion and migration capacity of EC109 cells in vitro.
|
25815591 |
2015 |
|
Lymphoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse.
|
25072059 |
2015 |
|
Thyroid Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
We designed and synthesized targeted ABCE1-siRNA sequences and a negative control sequence (NC-siRNA), and transfected them into human thyroid cancer SW579 cells by electrotransfer to obtain ABCE1-SW579 and NC-siRNA-SW579 cells (siRNA is small interfering RNA).
|
26600528 |
2015 |
|
Severe Combined Immunodeficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse.
|
25072059 |
2015 |
|
Thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We designed and synthesized targeted ABCE1-siRNA sequences and a negative control sequence (NC-siRNA), and transfected them into human thyroid cancer SW579 cells by electrotransfer to obtain ABCE1-SW579 and NC-siRNA-SW579 cells (siRNA is small interfering RNA).
|
26600528 |
2015 |
|
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse.
|
25072059 |
2015 |
|
Childhood Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse.
|
25072059 |
2015 |
|
Malignant neoplasm of mouth
|
0.010 |
Biomarker
|
group |
BEFREE |
ABCE1 is closely connected with the pathogenesis and development of oral cancer, which acts through the cellular pathways of 2-5A/RNase L.
|
25337191 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ABCE1 is closely connected with the pathogenesis and development of oral cancer, which acts through the cellular pathways of 2-5A/RNase L.
|
25337191 |
2014 |
|
Small cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
ABCE1 may be used as a potential target of gene therapy for small cell lung cancer in future.
|
20372810 |
2010 |
|
Prostatic Neoplasms
|
0.010 |
GeneticVariation
|
group |
LHGDN |
RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.
|
18189233 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The genes functions were related to a diverse cellular process including: (1) most of these genes were associated with CD4+ T cells functions, particularly related to cellular developments; (2) Ras pathway genes as RANBP10, GMIP, RASGRP2 and ARL5 might be responsible for the abnormal development of CD4+ T cells of SLE; (3) HIG2, TCF7, KHSRP, WWP1, SMAD3, TLK2, AES, CCNI and PIM2 belong to Wnt/beta-catenin way, they could play roles in modulating proliferation and differentiation of T lymphocytes; (4) uncertain viral infections may initiate autoimmunity because high levels expression genes were detected in T4-1s such as TRIM22, IER2, ABCE1, DUT, G1P2, G1P3, HNRPUL1, EVER2, IFNAR1, TNFSF14, TMP21 and PVRL2; and (5) apoptosis relating genes as EIF3S8, SH3BGRL3, GPX4, TOSO, PFDN5, BIN1, XIAPAF1, TEGT and CUGBP2 may contribute to over uploading of selfantigens in SLE cells.
|
16143398 |
2006 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that the ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients.
|
15809757 |
2005 |
|
Colonic Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
ABCE1, a member of ATP-binding cassette transporter gene, encodes peptides capable of inducing HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes in colon cancer patients.
|
15809757 |
2005 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate that the ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients.
|
15809757 |
2005 |
|
Liver diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Intrahepatic mRNA expression of interferon-inducible antiviral genes in liver diseases: dsRNA-dependent protein kinase overexpression and RNase L inhibitor suppression in chronic hepatitis C.
|
11050060 |
2000 |
|
Hepatitis C, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Also, the expression of the RNase L inhibitor showed a significant reduction in chronic hepatitis C (P =.0184).
|
11050060 |
2000 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
What's more, miR-153 over-expression inhibited tumorigenesis and ABCE1 expression, while increased miR-153 level in tumor tissues.
|
31306106 |
2019 |