GAS5, growth arrest specific 5, 60674

N. diseases: 184; N. variants: 5
Disease: Childhood Osteosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.040 AlteredExpression disease BEFREE Specifically, GAS5 overexpression in the U2OS osteosarcoma cell line induced <i>TP53</i>, <i>Bax</i> and <i>Bim</i> levels but inhibited <i>DDB2</i>, <i>TGFB</i> and <i>ROS1</i> expression, resulting in the inhibition of cell proliferation, invasion, colony formation and <i>in vivo</i> tumor formation. 31337976 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.040 Biomarker disease BEFREE This study was aimed to investigate the effect of lncRNA GAS5 on osteosarcoma and tried to decode the underling mechanisms. 29414815 2018
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.040 GeneticVariation disease BEFREE The genetic variant rs145204276 is functionally associated with the susceptibility of OS, which can function as a protective factor in the incidence of OS possibly through the regulation of GAS5. 30013899 2018
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.040 AlteredExpression disease BEFREE Overexpression of GAS5 suppressed the proliferation, migration, and epithelial-mesenchymal transition (EMT) of osteosarcoma cells. 28519068 2017