RORA, RAR related orphan receptor A, 6095

N. diseases: 158; N. variants: 54
Disease: Carcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 Biomarker phenotype BEFREE These findings highlight the important roles of genetic variations in circadian clock pathway genes play in colorectal cancer risk and suggest that RORA is potentially related to colorectal carcinogenesis. 29968159 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 PosttranslationalModification phenotype BEFREE To elucidate the mechanisms underlying such contrasting roles of PGE2 in tumorigenesis, we investigated all the previous experiments and found a new signal transduction pathway mediated by retinoic acid receptor-related orphan receptor (ROR)α, in which PGE2/PKCα-dependent phosphorylation of RORα attenuates Wnt target gene expression in colon cancer cells. 24831657 2014
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.030 Biomarker phenotype BEFREE Our results open new routes on the roles of RORα in glucose metabolism and carcinogenesis within cells of hepatic origin. 21818335 2011