|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The BCR-ABL1 fusion gene is the driver mutation of Philadelphia chromosome-positive chronic myeloid leukemia (CML).
|
31707540 |
2020 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Key genetic aberrations include the BCR-ABL1 gene rearrangement in Philadelphia chromosome-positive chronic myelogenous leukemia (CML) and JAK2/MPL/CALR aberrations in Philadelphia chromosome-negative MPNs.
|
29951914 |
2018 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase with MR<sup>4.5</sup> (BCR-ABL1⩽0.0032% on the International Scale (BCR-ABL1<sup>IS</sup>)) and ⩾2 years of frontline nilotinib therapy were enrolled.
|
28218239 |
2017 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The BCR-ABL1 transcript type influences response and outcome in Philadelphia chromosome-positive chronic myeloid leukemia patients treated frontline with imatinib.
|
28466557 |
2017 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to characterize the ABL1-BCR fusion gene in 76 BCR-ABL1-positive chronic myeloid leukemia (CML) patients regarding expression as well as genomic status, to assess the frequency of ABL1-BCR gene deletion in these patients, which has been reported to be an adverse prognostic factor in Philadelphia chromosome-positive CML.
|
11979553 |
2002 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The breakpoint cluster region site in patients with Philadelphia chromosome-positive chronic myelogenous leukemia. Clinical, laboratory, and prognostic correlations.
|
8625225 |
1995 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Quantification of the breakpoint cluster region rearrangement for clinical monitoring in Philadelphia chromosome-positive chronic myeloid leukemia.
|
7742530 |
1995 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the breakpoints of the bcr gene in 46 Ph1-positive CML cases by Southern blot analysis of bcr rearrangement, and in 17 CML cases by a combination of Southern blot analysis and RT-PCR.
|
7948305 |
1994 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The positions of the breakpoint within the breakpoint cluster region (bcr) on the bcr-abl gene in 22 chronic-phase cases of Ph1-positive CML were determined using conventional Southern blots, and the splicing pattern were also determined the species of the fused bcr-abl mRNA in 79 CML cases using the polymerase chain-reaction procedure (RT-PCR).
|
8374529 |
1993 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No correlation between site of breakpoint in the BCR gene and platelet counts in Philadelphia chromosome-positive CML.
|
1405723 |
1992 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
M-BCR breakpoint location does not predict survival in Philadelphia chromosome-positive chronic myeloid leukemia.
|
1398276 |
1992 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Leukemia cells from adults with Philadelphia (Ph1)-chromosome positive chronic myelogenous leukemia (CML) have a characteristic molecular rearrangement between the BCR and ABL genes whereby major breakpoint cluster region (Mbcr) exons 2 or 3 are joined to ABL exon II.
|
1932752 |
1991 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Philadelphia chromosome-positive chronic myelogenous leukemia with deleted fusion of BCR and ABL genes.
|
2157692 |
1990 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous reports have indicated that mutations of the RAS oncogenes are not associated with the chronic phase of Philadelphia chromosome-positive chronic myelogenous leukemia (Ph1+ CML).
|
2205309 |
1990 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The standard t(9;22)(q34;q11) found in Philadelphia (Ph) chromosome positive chronic myeloid leukemia (CML) involves a highly restricted (5.8 kb) chromosome 22 breakpoint cluster region (bcr), which results in the formation of a chimeric gene comprising exons from the 5' end of bcr and protooncogene c-abl coding sequences from chromosome 9.
|
2649233 |
1989 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It seems that genomic alterations within bcr and abl cannot account, alone, for the duration of the chronic phase of Ph1 positive CML and those quantitative and/or qualitative alterations of the p210 bcr/abl protein, unluckily awkward to prove, might be responsible for the atypical clinical features of these CML long survivors.
|
2733455 |
1989 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Basophils exhibit rearrangement of the bcr gene in Philadelphia chromosome-positive chronic myeloid leukemia.
|
3258049 |
1988 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
T lymphocytes lack rearrangement of the bcr gene in Philadelphia chromosome-positive chronic myelocytic leukemia.
|
3495303 |
1987 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The breakpoint cluster region (bcr) that is rearranged in all patients with Philadelphia chromosome positive chronic myeloid leukemia, was normal in all cases, including at least one patient with Philadelphia chromosome positive ALL.
|
3011151 |
1986 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to JCML, PB from six adults with Philadelphia (Ph1) chromosome-positive chronic myelogenous leukemia (Ph1 + CML) yielded CSA-dependent CFU-C colonies which were composed of granulocytes, macrophages, or both, as well as exuberant growth of BFU-E colonies.
|
3486010 |
1986 |
|
Philadelphia chromosome positive chronic myelogenous leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The reported cases of near-haploidy with Ph1-positive CML and those with constitutional translocations with CML have been tabulated and the possible significance of the cytogenetic abnormalities discussed.
|
6932994 |
1980 |