RPS6KA1, ribosomal protein S6 kinase A1, 6195

N. diseases: 68; N. variants: 6
Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE We found that RSK1 promoted tumor growth and metastasis in vivo. 29498411 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE Finally, <i>in vivo</i> studies revealed that the hormone activates RSK in xenografts tumor. 28385776 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 AlteredExpression group BEFREE Mechanistically, downregulation of HERV-K blocked expression of tumor-associated genes that included Ras, p-RSK, and p-ERK. 27557521 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). 27236820 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE The K17-hnRNP K partnership is regulated by the ser/thr kinase RSK and required for CXCR3-dependent tumor cell growth and invasion. 25713416 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 Biomarker group BEFREE Several studies implicate the RSK pathway as being pivotal for the growth and proliferation of CSCs, which are postulated to drive tumor relapse. 26011941 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 AlteredExpression group BEFREE In paraffin-embedded, formalin-fixed tissues from core needle biopsy tissues from 112 patients, positive phospho-p90RSK expression was associated with greater tumor shrinkage and smaller post-chemotherapy tumor size. 23216670 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 AlteredExpression group BEFREE While in lung and other tumors RSK may control apoptosis via estrogen-mediated regulation of mitochondrial integrity. 20045011 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.090 PosttranslationalModification group BEFREE RSK1 phosphorylation of Ser-1798 inhibits the tumor suppressor function of the tuberin/hamartin complex, resulting in increased mTOR signaling to S6K1. 15342917 2004