|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ribosomal S6 Kinase 2 (RSK2) is a downstream target of ERK1/2 in MAPK/ERK pathway and inhibition of RSK2 suppresses the tumorigenesis and metastasis of neoplasm.
|
31207212 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RSK2 physically interacted with ERα through its N terminus to activate a proneoplastic transcriptional network critical to the ER<sup>+</sup> lineage in the mammary gland, thereby providing a gene signature that effectively stratified patient tumors according to ERα status.
|
29351904 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RSK2 is a serine/threonine kinase and a member of the p90 ribosomal S6 kinase (p90<sup>RSK</sup>; RSKs) family, which regulates cell proliferation and transformation induced by tumor promoters such as epithelial growth factor (EGF), 12-O-tetradecanoylphorbol-13-acetate (TPA), and ultraviolet (UV) radiation.
|
28013489 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, <i>in vivo</i> studies revealed that the hormone activates RSK in xenografts tumor.
|
28385776 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mechanistically, downregulation of HERV-K blocked expression of tumor-associated genes that included Ras, p-RSK, and p-ERK.
|
27557521 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In agreement with the in vitro data, using public datasets, we find that RSK2 is significantly upregulated in vivo in human GBM patient tumors, and that high RSK2 expression significantly correlates with advanced tumor stage and poor patient survival.
|
27829215 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We validated performance of the test with its established parameters, using five published data sets comprising 15,758 known independent tumor pairs (maximum CLS = 4.1%, minimum p-value = 0.48) and 283 known tumor clonal pairs (minimum CLS 13%, maximum p-value <0.01), across renal cell, testicular, and colorectal cancer.
|
26554380 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Several studies implicate the RSK pathway as being pivotal for the growth and proliferation of CSCs, which are postulated to drive tumor relapse.
|
26011941 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The K17-hnRNP K partnership is regulated by the ser/thr kinase RSK and required for CXCR3-dependent tumor cell growth and invasion.
|
25713416 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nude mouse tumor xenograft model was built to understand the interaction between myricetin and NTD RSK2.
|
25192723 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RSK2 functions downstream of Ras/Raf and promotes tumor cell motility and metastasis.
|
23118220 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results in estrogen-unresponsive fibroblasts, ribosomal S6 kinase 2 kinase (RSK2) knockout cells, and estrogen receptor (ER)-deficient breast tumor cells show that kurarinone can inhibit tumor cell proliferation and selectively block nuclear NFκB transactivation of specific target genes such as IL6, cyclin D1, SOD2 but not TNFAIP2.
|
21831037 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
While in lung and other tumors RSK may control apoptosis via estrogen-mediated regulation of mitochondrial integrity.
|
20045011 |
2010 |