|
Clinodactyly of the 5th finger
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of pulmonary valve
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Aplasia of the semicircular canal
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormal hair quantity
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the spleen
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Tools to study the function of the Ras-related, estrogen-regulated growth inhibitor in breast cancer.
|
18374156 |
2008 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
All three were observed in phenotype-specific breast cancer cell lines, normal (nontransformed) breast cell lines, and primary breast epithelial cells by Western blotting, but only cofilin-1 and p23 were detected by multiple reaction monitoring mass spectrometry analysis.
|
24106833 |
2013 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
The Ras-related gene ERAS is involved in human and murine breast cancer.
|
30158566 |
2018 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Recent studies have found that high level of p23 may promote tumor progression and poor prognosis in breast cancer patients. p23 was found to be overexpressed in our previous microarray assay of 100 childhood acute lymphoblastic leukemia (ALL) bone marrow (BM) samples.
|
22677230 |
2012 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
High nuclear p23 was found to be associated with high cytoplasmic p23, therefore both may promote tumor progression and poor prognosis by increasing metastatic potential and drug resistance in breast cancer patients.
|
20847343 |
2010 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Contradicting the positive association reported in previous studies, our results indicate that R-Ras activation may negatively regulate the transformation of breast epithelial cells, and the loss of activation of R-Ras may be involved in the carcinogenesis of breast cancer.
|
24700169 |
2014 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Consequently, it is important not to dismiss the Ras pathway in the development of breast cancer merely because of the infrequent detection of mutations in ras itself, but rather to consider the influence of aberrations upstream or downstream of Ras and of certain Ras-related proteins in the development of breast cancer.
|
7612899 |
1995 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells.
|
12386818 |
2002 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
This makes p23 an attractive target for combating tumor cell metastasis in breast cancer patients.
|
22074947 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We report a case of acute myeloid leukemia (M5a of the FAB classification), secondary to the myelodysplastic syndrome, showing a deletion of the short arm of chromosome 2 at p23 in the bone marrow cells.
|
8500100 |
1993 |
|
Leukemia, Myelocytic, Acute
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We report a case of acute myeloid leukemia (AML) [FAB-M5a] showing a deletion of the short arm of chromosome 2 at band p23 as a sole abnormality in the bone marrow cells.
|
12034535 |
2002 |
|
Leukemia, Myelocytic, Acute
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In addition, there is a significant association between class I and class II mutations possibly indicating cooperation in leukemogenesis, and between mutations of AML1 and RAS related to subsequent progression from t-MDS to t-AML.
|
16990778 |
2006 |
|
Leukemia, Myelocytic, Acute
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We also identified somatic RRAS mutations (p.Gly39dup and p.Gln87Leu) in 2 of 110 cases of non-syndromic juvenile myelomonocytic leukaemia, a childhood myeloproliferative/myelodysplastic disease caused by upregulated RAS signalling, defining an atypical form of this haematological disorder rapidly progressing to acute myeloid leukaemia.
|
24705357 |
2014 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical studies have demonstrated increased p23 expression in advanced prostate cancer.
|
25241147 |
2015 |
|
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The 8p22 through p23 region has been identified as a potential site for genes associated with prostate cancer.
|
12377406 |
2002 |
|
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
In human prostate tumors, nuclear p23 was higher in malignant prostate cells compared with benign/normal cells, supporting the utility of p23 as a therapeutic target in prostate cancer.
|
22899854 |
2012 |
|
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
These results highlight a previously uncharacterized subfamily of Ras-related genes that may have a tumor suppressor role in prostate cancer.
|
15033445 |
2004 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the steady-state p23 levels are reduced in the brains of individuals with AD.
|
18652896 |
2008 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
While patients with severe AD did display a consistent reduction in p23 levels, our inability to observe p19 in mouse or human AD brain samples suggests that the usefulness of the p23 neo-epitope antibody is restricted to cells and primary neurons undergoing cellular stress.
|
21691801 |
2012 |
|
Malignant tumor of cervix
|
0.020 |
Biomarker
|
disease |
BEFREE |
We previously reported that expression of an oncogenic form of R-Ras (R-Ras87L) in a cell line of cervical cancer (C33A cells) augments cell growth in vitro and tumorigenicity in vivo.
|
16862428 |
2007 |