RRAS, RAS related, 6237

N. diseases: 149; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs34647824
rs34647824
Entrez Id: 6237
Gene Symbol: RRAS
RRAS
CUI: C0017654
Disease:
Glomerular Filtration Rate 		A 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs61760904
rs61760904
Entrez Id: 6237
Gene Symbol: RRAS
RRAS
CUI: C0871470
Disease:
Systolic Pressure 		T 0.700 GeneticVariation GWASCAT Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. 27618447 2016
dbSNP: rs368625677
rs368625677
Entrez Id: 6237
Gene Symbol: RRAS
RRAS
CUI: C0028326
Disease:
Noonan Syndrome 		0.010 GeneticVariation BEFREE We report on two germline mutations (p.Gly39dup and p.Val55Met) in RRAS, a gene encoding a small monomeric GTPase controlling cell adhesion, spreading and migration, underlying a rare (2 subjects among 504 individuals analysed) and variable phenotype with features partially overlapping Noonan syndrome, the most common RASopathy. 24705357 2014