RXRA, retinoid X receptor alpha, 6256

N. diseases: 132; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.510 GeneticVariation group LHGDN Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha. 18162523 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.510 Biomarker group CTD_human Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium. 15318950 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.510 Biomarker group RGD Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium. 15318950 2004
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.310 Biomarker disease CTD_human Cancer-related genes transcriptionally induced by the fungicide penconazole. 23811263 2014
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.310 Biomarker disease BEFREE We found an abnormal expression of RARA, RARB, RXRA, and RXRB in 67, 69, 66, and 73 %, respectively, of thyroid carcinomas (n = 78) and in 9, 9, 9, and 33 % of follicular adenomas (n = 33) (p < 0.001). 23639973 2013
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.310 AlteredExpression disease BEFREE Decreased retinoid X receptor-alpha protein expression in basal cells occurs in the early stage of human prostate cancer development. 15006913 2004
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.310 Biomarker disease CTD_human Cross-species global and subset gene expression profiling identifies genes involved in prostate cancer response to selenium. 15318950 2004
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma 		0.300 Biomarker disease CTD_human MicroRNA and mRNA features of malignant pleural mesothelioma and benign asbestos-related pleural effusion. 25756049 2015
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.300 Biomarker disease CTD_human Cancer-related genes transcriptionally induced by the fungicide penconazole. 23811263 2014
CUI: C0151468
Disease: Thyroid Gland Follicular Adenoma
Thyroid Gland Follicular Adenoma 		0.300 Biomarker disease CTD_human Cancer-related genes transcriptionally induced by the fungicide penconazole. 23811263 2014
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy 		0.300 Biomarker disease CTD_human Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury. 16782282 2006
CUI: C0154748
Disease: Lesion of Sciatic Nerve
Lesion of Sciatic Nerve 		0.300 Biomarker disease CTD_human Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury. 16782282 2006
CUI: C0242013
Disease: Sciatic Neuritis
Sciatic Neuritis 		0.300 Biomarker disease CTD_human Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury. 16782282 2006
CUI: C0751924
Disease: Neuralgia-Neuritis, Sciatic Nerve
Neuralgia-Neuritis, Sciatic Nerve 		0.300 Biomarker disease CTD_human Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury. 16782282 2006
CUI: C0751925
Disease: Sciatic Nerve Palsy
Sciatic Nerve Palsy 		0.300 Biomarker disease CTD_human Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury. 16782282 2006
CUI: C1862939
Disease: AMYOTROPHIC LATERAL SCLEROSIS 1
AMYOTROPHIC LATERAL SCLEROSIS 1 		0.300 Biomarker disease CTD_human Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. 11796754 2002
CUI: C1862941
Disease: Amyotrophic Lateral Sclerosis, Sporadic
Amyotrophic Lateral Sclerosis, Sporadic 		0.300 Biomarker disease CTD_human Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. 11796754 2002
CUI: C4551993
Disease: Amyotrophic Lateral Sclerosis, Familial
Amyotrophic Lateral Sclerosis, Familial 		0.300 Biomarker disease CTD_human Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. 11796754 2002
CUI: C0007192
Disease: Cardiomyopathy, Alcoholic
Cardiomyopathy, Alcoholic 		0.200 Biomarker disease RGD [Peroxisome proliferator-activated receptor alpha and retinoid X receptor alpha expressions and intervention in alcoholic cardiomyopathy rats]. 19791468 2009
CUI: C0243026
Disease: Sepsis
Sepsis 		0.200 Biomarker disease RGD Retinoid X receptor alpha participation in dexamethasone-induced rat bile acid coenzyme A-amino acid N-acyltransferase expression in septic liver. 19008781 2009
CUI: C0019284
Disease: Diaphragmatic Hernia
Diaphragmatic Hernia 		0.200 Biomarker phenotype RGD Disturbance of retinol transportation causes nitrofen-induced hypoplastic lung. 17270546 2007
CUI: C0023904
Disease: Liver Neoplasms, Experimental
Liver Neoplasms, Experimental 		0.200 Biomarker phenotype RGD Expression of retinoid X receptor alpha is decreased in 3'-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats. 17786350 2007
CUI: C0243026
Disease: Sepsis
Sepsis 		0.200 Biomarker disease RGD Role of retinoid-X receptor-alpha in the suppression of rat bile acid coenzyme A-amino acid N-acyltransferase in liver during sepsis. 17483744 2007
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.200 Biomarker phenotype RGD Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers. 16344269 2006
CUI: C0043020
Disease: Wallerian Degeneration
Wallerian Degeneration 		0.200 Biomarker phenotype RGD Regulation of retinoic acid receptors alpha, beta and retinoid X receptor alpha after sciatic nerve injury. 16782282 2006