Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease.
|
29249680 |
2018 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD.
|
26806863 |
2016 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, it seems that the BDNF gene does not contribute significantly to the risk of AD or PD in Finnish patients.
|
16565926 |
2006 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The influence of a common functional polymorphism of the BDNF gene on the risk of developing dyskinesias in a large cohort of patients with PD (n = 315), who were independently and variably treated with levodopa and/or other dopaminergic treatments, was investigated.
|
18977816 |
2009 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, BDNF G196A (Val66Met) is confirmed to be a risk factor for cognitive impairment in PD.
|
31365694 |
2019 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall, these findings suggest that harboring the BDNF val/val genotype in PD leads to a set of cortical and subcortical brain alterations that could promote cognitive decline in this population.
|
31202861 |
2019 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several genetic studies have shown a significant association between schizophrenia, Alzheimer's disease, and Parkinson's disease and certain BDNF polymorphisms, specifically rs6265;rs759834365" genes_norm="627">G196A (rs6265) and C270T (rs56164415).
|
28539884 |
2017 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gami-Chunggan Formula Prevents Motor Dysfunction in MPTP/p-Induced and A53T α-Synuclein Overexpressed Parkinson's Disease Mouse Model Though DJ-1 and BDNF Expression.
|
31555122 |
2019 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Brain-derived neurotrophic factor G196A polymorphism and clinical features in Parkinson's disease.
|
20085561 |
2010 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied two genetic polymorphisms (240C/T and 480G/A) of the brain-derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275).
|
15838855 |
2005 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sixteen polymorphisms in candidate genes belonging to five neurotransmitter systems (dopaminergic, catecholaminergic, serotonergic, glutamatergic, opioidergic) and the BDNF were screened in 154 PD patients with addictive behaviors and 288 PD control subjects.
|
27237108 |
2016 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested a novel association between BDNF 712A/G AG/AA genotypes and PD in a Chinese Han population.
|
21510922 |
2011 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research.
|
31104169 |
2019 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that the APOE ε4 allele is associated with a higher risk for PD-D. Gene-gene interaction analysis revealed that three significant gene-gene interactions, including BDNF and CLU, APOE and CR1, and DYRK1A and CD2AP increase the risk for PD.
|
29698690 |
2018 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
BDNF (rs6265) and CRY1 (rs2287161) variants have been associated with more depressive symptoms in people with PD.
|
31292011 |
2020 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Dopamine receptors and BDNF-haplotypes predict dyskinesia in Parkinson's disease.
|
29191473 |
2018 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, our negative findings suggest that it is unlikely that the BDNF Val66Met polymorphism plays a major role in the pathogenesis of PD in the Chinese population.
|
14642442 |
2003 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD).
|
29896439 |
2018 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association studies of BDNF variants reveal no associations with Parkinson's disease.
|
15666411 |
2005 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To date, there have been several conflicting reports on the correlation between AD or PD and Val66Met or C270T polymorphism in the BDNF promoter region, although no data on this relationship have been published with respect to dementia with Lewy bodies (DLB).
|
16899999 |
2006 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD.
|
25431370 |
2015 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results do not support a major role for the BDNF Val66Met polymorphism in PD in the Greek population.
|
22001244 |
2011 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association between brain-derived neurotrophic factor G196A polymorphism and clinical features of Parkinson's disease.
|
24051673 |
2013 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results do not provide statistically significant evidence that common genetic variability in BDNF would associate with the risk for PD in the Caucasian populations studied here.
|
17229524 |
2007 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism.
|
31197095 |
2019 |