BDNF, brain derived neurotrophic factor, 627

N. diseases: 852; N. variants: 49
Disease: Parkinson Disease ×
Source: BEFREE ×
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE BDNF (rs6265) and CRY1 (rs2287161) variants have been associated with more depressive symptoms in people with PD. 31292011 2020
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. 31197095 2019
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Pattern of cortical thinning associated with the BDNF Val66Met polymorphism in Parkinson's disease. 31202861 2019
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. 31365694 2019
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research. 31104169 2019
dbSNP: rs746682028
rs746682028
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. 31365694 2019
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Pattern of cortical thinning associated with the BDNF Val66Met polymorphism in Parkinson's disease. 31202861 2019
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. 31365694 2019
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were influenced by brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. 31197095 2019
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research. 31104169 2019
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). 29896439 2018
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE A total of 27 individuals (age = 65.4 ± 8.1 years; males = 14, females = 13) with neurologist-diagnosed PD with 13 genotyped for BDNF as Val66Val, 11 as Val66Met, 2 as Met66Met (1 refused). 29547479 2018
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease. 29249680 2018
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE We examined if the single nucleotide variant rs6265 in the gene Bdnf alters clinical phenotype in early-stage, unmedicated PD. 29759928 2018
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Here we review the role and relevance of the BDNF Val66Met polymorphism in neurodegenerative diseases, with particular emphasis on glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). 29896439 2018
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE A total of 27 individuals (age = 65.4 ± 8.1 years; males = 14, females = 13) with neurologist-diagnosed PD with 13 genotyped for BDNF as Val66Val, 11 as Val66Met, 2 as Met66Met (1 refused). 29547479 2018
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE To determine whether dopaminergic (rs1076560 DRD2 G > T and rs4680 catechole-o-methyltranspherase (COMT) Val158Met) or brain derived neurotrophic factor (rs6265 BDNF Val66Met) genetic polymorphisms are associated with gait function and medication responsiveness in Parkinson's disease. 29249680 2018
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165 2017
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms. 27852165 2017
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD. 26806863 2016
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE These results suggest a role for BDNF Val66Met polymorphism on cognitive impairment in PD. 26806863 2016
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD. 25431370 2015
dbSNP: rs6265
rs6265
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE The Val66Met polymorphism of BDNF (rs6265) has been associated with functional differences (mainly cognitive) between healthy adults and also with differences in the clinical expression of several other neuropsychiatric illnesses including PD. 25444596 2015
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE The Val66Met polymorphism of BDNF (rs6265) has been associated with functional differences (mainly cognitive) between healthy adults and also with differences in the clinical expression of several other neuropsychiatric illnesses including PD. 25444596 2015
dbSNP: rs759834365
rs759834365
Entrez Id: 627;497258
Gene Symbol: BDNF;BDNF-AS
BDNF;BDNF-AS
CUI: C0030567
Disease:
Parkinson Disease 		0.100 GeneticVariation BEFREE Our data do not support a major role for the BDNF Val66Met polymorphism in the pathogenesis of PD. 25431370 2015