BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Disease: Chronic pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 Biomarker phenotype BEFREE <b>Rationale:</b> Brain-derived neurotrophic factor (BDNF) is a key mediator in the development of chronic pain. 31037129 2019
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 Biomarker phenotype BEFREE Because of the relationship between dynorphin and the brain-derived neurotrophic factor, and the role of this neurotrophin in chronic pain-related neuroplasticity, we investigated brain-derived neurotrophic factor gene (Bdnf) expression in the areas showing Pdyn or Oprk1 mRNAs changes. 29430855 2019
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 Biomarker phenotype BEFREE Brain-derived neurotrophic factor (BDNF) is considered an important modulator for mediating nociceptive pathways in chronic pain. 31632254 2019
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 AlteredExpression phenotype BEFREE In the rACC, brain-derived neurotrophic factor (BDNF), an activity-dependent neuromodulator, has been shown to play a role in the development and persistence of chronic pain. 29353374 2018
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 Biomarker phenotype BEFREE Brain-derived neurotrophic factor (BDNF) is a regulator for the formation and maintenance of chronic pain in various chronic disorders and has been shown to increase in the serum of women with endometriosis. 28954602 2018
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 Biomarker phenotype BEFREE Although the brain-derived neurotrophic factor (BDNF) has been intensively investigated in animal models of chronic pain, its role in human pain processing is less understood. 29294124 2018
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 AlteredExpression phenotype BEFREE We evaluated the effect of chronic pain on the glutamate and GABA levels and BDNF expression in the CA1 region of hippocampus as a possible explanation for memory impairment related to neuropathic pain. 28336100 2017
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 Biomarker phenotype BEFREE The neurotrophin nerve growth factor (NGF) has been implicated as a key mediator of chronic pain. 27779399 2017
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 Biomarker phenotype BEFREE Brain-derived neurotrophic factor (BDNF) plays a key role in the production of central sensitization and contributes to chronic pain conditions. 25383981 2014
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 Biomarker phenotype RGD Thus, we characterized the actions of 4-MC on TrkB receptor-related pERK and BDNF mRNA in discreet brain regions related to pain-emotion after chronic pain in rat. 24518228 2014
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 AlteredExpression phenotype BEFREE Expression of brain-derived neurotrophic factor (BDNF) was stimulated in human neuroblastoma SH-SY5Y cells by a nonprotein extract of inflamed rabbit skin inoculated with vaccinia virus (Neurotropin), an analgesic widely used in Japan for treatment of disorders associated with chronic pain, with the optimal dosage at 10mNU/mL. 20600926 2010
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 GeneticVariation phenotype BEFREE However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain. 21049025 2010
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.300 Biomarker phenotype RGD Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain. 11360665 2000