Cocaine Dependence
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Additionally, while BDNF is strongly regulated by serotonin levels and inherited serotonin transporter down-regulation is associated with increased vulnerability to cocaine addiction, the effects of serotonin transporter genotype on BDNF signaling in the amygdala under naïve and cocaine exposure conditions are unknown.
|
31606593 |
2019 |
Cocaine Dependence
|
0.330 |
Biomarker
|
disease |
BEFREE |
Thus, activity in the PrL-NAc pathway is responsible for the therapeutic effect of BDNF on cocaine-seeking whereas inhibition of activity in the PrL-pPVT pathway elicits a similar therapeutic effect in the absence of BDNF.<b>SIGNIFICANCE STATEMENT</b> The major issue in cocaine addiction is the high rate of relapse.
|
30185459 |
2018 |
Cocaine Dependence
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Effects of crack cocaine addiction and stress-related genes on peripheral BDNF levels.
|
28237884 |
2017 |
Cocaine Dependence
|
0.330 |
Biomarker
|
disease |
CTD_human |
MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212.
|
20711185 |
2010 |
Cocaine Dependence
|
0.330 |
Therapeutic
|
disease |
CTD_human |
Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine.
|
20810894 |
2010 |
Cocaine Dependence
|
0.330 |
Biomarker
|
disease |
CTD_human |
Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine.
|
20810894 |
2010 |
Cocaine Dependence
|
0.330 |
Therapeutic
|
disease |
CTD_human |
MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212.
|
20711185 |
2010 |
Cocaine Dependence
|
0.330 |
Therapeutic
|
disease |
CTD_human |
A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens.
|
19321768 |
2009 |
Cocaine Dependence
|
0.330 |
Biomarker
|
disease |
CTD_human |
A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens.
|
19321768 |
2009 |
Cocaine Dependence
|
0.330 |
Biomarker
|
disease |
CTD_human |
Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats.
|
18311559 |
2008 |
Cocaine Dependence
|
0.330 |
Therapeutic
|
disease |
CTD_human |
Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats.
|
18311559 |
2008 |
Cocaine Dependence
|
0.330 |
Therapeutic
|
disease |
CTD_human |
Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse.
|
17618281 |
2007 |
Cocaine Dependence
|
0.330 |
Biomarker
|
disease |
CTD_human |
Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse.
|
17618281 |
2007 |
Cocaine Dependence
|
0.330 |
Therapeutic
|
disease |
CTD_human |
A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats.
|
17651427 |
2007 |
Cocaine Dependence
|
0.330 |
Biomarker
|
disease |
CTD_human |
A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats.
|
17651427 |
2007 |
Cocaine Dependence
|
0.330 |
Therapeutic
|
disease |
CTD_human |
A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal.
|
14973246 |
2004 |
Cocaine Dependence
|
0.330 |
Biomarker
|
disease |
CTD_human |
A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal.
|
14973246 |
2004 |