Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NT-3 protein expression was then studied in 47 human pancreatic cancers, using a monoclonal antibody against human NT-3 protein.
|
9196438 |
1997 |
Coronary Arteriosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also identify SORT1 and CELSR2 as candidate susceptibility genes for a locus recently associated with coronary artery disease and plasma low-density lipoprotein cholesterol levels in the process.
|
18462017 |
2008 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also identify SORT1 and CELSR2 as candidate susceptibility genes for a locus recently associated with coronary artery disease and plasma low-density lipoprotein cholesterol levels in the process.
|
18462017 |
2008 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also identify SORT1 and CELSR2 as candidate susceptibility genes for a locus recently associated with coronary artery disease and plasma low-density lipoprotein cholesterol levels in the process.
|
18462017 |
2008 |
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
NTR3 mRNA expression was observed in all examined samples and was higher in the adenomas, both functioning and nonfunctioning, compared to normal pituitary.
|
18624930 |
2008 |
Adenoma
|
0.020 |
Biomarker
|
group |
LHGDN |
NTR3 mRNA expression was observed in all examined samples and was higher in the adenomas, both functioning and nonfunctioning, compared to normal pituitary.
|
18624930 |
2008 |
Obesity
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Sortilin, an essential player in adipocyte and muscle glucose metabolism through the control of GLUT4 localisation, is downregulated in obesity and TNF-alpha is likely to be involved in this defect.
|
19219422 |
2009 |
Coronary Arteriosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
|
19660754 |
2010 |
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The rs599839 polymorphism A/G in the vicinity of the sortilin 1 gene has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD).
|
19837406 |
2010 |
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
|
19660754 |
2010 |
Coronary heart disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
|
19660754 |
2010 |
Myocardial Infarction
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
An accompanying study in Nature identified SORT1 as the causal gene at the 1p13 locus and showed that increased expression of sortilin-1 protein in liver was associated with lower LDL-C levels and a reduced risk of myocardial infarction.
|
20826839 |
2010 |
Myocardial Infarction
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Association of the single nucleotide polymorphism rs599839 in the vicinity of the sortilin 1 gene with LDL and triglyceride metabolism, coronary heart disease and myocardial infarction. The Ludwigshafen Risk and Cardiovascular Health Study.
|
19837406 |
2010 |
Hypercholesterolemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Absence of sortilin in gene-targeted mice reduces secretion of lipoproteins from the liver and ameliorates hypercholesterolemia and atherosclerotic lesion formation in LDL receptor-deficient animals.
|
20816088 |
2010 |
Frontotemporal dementia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sortilin-mediated PGRN endocytosis is likely to play a central role in FTLD-TDP pathophysiology.
|
21092856 |
2010 |
Atherosclerotic lesion
|
0.020 |
Biomarker
|
disease |
BEFREE |
Absence of sortilin in gene-targeted mice reduces secretion of lipoproteins from the liver and ameliorates hypercholesterolemia and atherosclerotic lesion formation in LDL receptor-deficient animals.
|
20816088 |
2010 |
Coronary Arteriosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our initial studies revealed increased levels of sortilin in post-mortem brain tissue of AD patients and that overexpression of sortilin leads to increased BACE1-mediated cleavage of APP in cultured cells.
|
21245145 |
2011 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002).
|
22152955 |
2011 |
Myocardial Infarction
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Our results establish two SNPs, rs17465637 in MIA3 and rs599839 near SORT1 as significant risk factors for MI in the American Genebank Caucasian population.
|
21463265 |
2011 |
Myocardial Infarction
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Additionally, there is evidence for concordance of SNP associations with both CAC and MI at a number of other loci, including 3q22 (MRAS gene), 13q34 (COL4A1/COL4A2 genes), and 1p13 (SORT1 gene).
|
22144573 |
2011 |
Neurodegenerative Disorders
|
0.050 |
Biomarker
|
group |
BEFREE |
Massively parallel sequencing and splicing-sensitive junction arrays revealed that levels of 601 mRNAs were changed (including Fus (Tls), progranulin and other transcripts encoding neurodegenerative disease-associated proteins) and 965 altered splicing events were detected (including in sortilin, the receptor for progranulin) following depletion of TDP-43 from mouse adult brain with antisense oligonucleotides.
|
21358643 |
2011 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In contrast to BDNF, exogenous pro-BDNF induced CRC apoptosis, which suggests that a counterbalance mechanism is involved in the control of CRC cell survival, through sortilin as the co-receptor for p75(NTR), the high affinity receptor for pro-neurotrophins.
|
21966426 |
2011 |
Alzheimer disease, familial, type 3
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our initial studies revealed increased levels of sortilin in post-mortem brain tissue of AD patients and that overexpression of sortilin leads to increased BACE1-mediated cleavage of APP in cultured cells.
|
21245145 |
2011 |