SORT1, sortilin 1, 6272

N. diseases: 111; N. variants: 8
Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.020 Biomarker phenotype BEFREE Using sortilin-deficient mice or receptor inhibition by antibodies or a small-molecule antagonist, we lastly demonstrate that we are able to fully block BDNF-induced pain and alleviate injury-induced neuropathic pain, validating sortilin as a clinically relevant target. 31223654 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.020 Biomarker phenotype BEFREE The interaction of sortilin to these neurotrophic ligands is linked to diseases of the nervous system that lead to neurodegeneration and neuropathic pain. 29067536 2018