SORT1, sortilin 1, 6272

N. diseases: 111; N. variants: 8
Disease: Vascular calcification ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.030 Biomarker phenotype BEFREE We previously demonstrated that sortilin promotes vascular calcification via its trafficking of tissue-nonspecific alkaline phosphatase to EVs. 29382723 2018
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.030 Biomarker phenotype BEFREE Genome-wide association studies and preclinical studies demonstrated a role of sortilin in lipid metabolism, inflammation, and vascular calcification-all cardiovascular risk factors. 28279970 2017
CUI: C0342649
Disease: Vascular calcification
Vascular calcification 		0.030 Biomarker phenotype BEFREE Additionally, transfer of sortilin-deficient BM cells to irradiated atherosclerotic mice did not affect vascular calcification, indicating a primary role of SMC-derived sortilin. 26950419 2016