|
Psoriasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A potential association between psoriasin to rs4819554 of IL-17RA gene polymorphism in psoriasis Egyptian patients.
|
31745628 |
2020 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since the mechanisms underlying S100A7 regulation and function remain elusive, a better understanding of these mechanisms may be useful to uncover additional treatment approaches for psoriasis.
|
30710307 |
2019 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
S100A7, Jab1, and p27<sup>kip1</sup> expression in psoriasis and S100A7 CRISPR-activated human keratinocyte cell line.
|
30203426 |
2019 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serum psoriasin and koebnerisin correlate with IMT, underlining their value as a potential link between psoriasis and atherosclerosis.
|
29333662 |
2018 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We speculate that the biological network of MSX2P1-miR-6731-5p-S100A7 is a potential novel therapeutic target for the future treatment of psoriasis.
|
29339075 |
2018 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
EISO had no impact on the phenotype of the normal skin tissue model, however, EISO treatment of the psoriasis tissue model reverted psoriatic pathology as demonstrated by histologic characterization and expression of keratinocyte proliferation markers, Ki67 and psoriasin.
|
28360856 |
2017 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data link the disease-intrinsic danger signals psoriasin (S100A7) and dsDNA for NLPR1-dependent caspase-5 activity in psoriasis providing potential therapeutic targets in Th17-mediated skin autoinflammation.
|
28422993 |
2017 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Psoriasin expression remains high in patients with psoriasis, whereas it is downregulated in patients with invasive breast carcinoma.
|
28565822 |
2017 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that psoriasin contributes to the dysregulated differentiation process in the psoriasis epidermis.
|
27958610 |
2017 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis.
|
28060905 |
2017 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Circulating leukocytes (PBMCs) of patients with psoriasis produced increased levels of koebnerisin and psoriasin compared to healthy individuals.
|
26055798 |
2015 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast, other antimicrobial peptides expressed in psoriatic skin including elafin, hBD1, and psoriasin (S100A7) did not show similar activities. hBD2, hBD3, and lysozyme were detected in psoriatic skin lesions in the vicinity of pDCs and found to cooperate with LL37 to induce high levels of IFN production by pDCs, suggesting their concerted role in the pathogenesis of psoriasis.
|
25332209 |
2015 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Egr-1 is a key regulator of IL-17A-induced psoriasin upregulation in psoriasis.
|
25256120 |
2014 |
|
Psoriasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Psoriasin (S100A7), originally identified in psoriasis, is a calcium-binding protein belonging to the multigenic S100 family.
|
22189627 |
2012 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Psoriasin was overexpressed in psoriasis, CULP and SCC compared with healthy skin.
|
22998543 |
2012 |
|
Psoriasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
With four regression models obtained, two SNPs rs9468925 in HLA-C/HLA-B and rs2858881 in HLA-DQA2 were repeatedly selected in all models, suggesting that multiple loci outside PSOR1 locus were associated with psoriasis.
|
22125590 |
2011 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Psoriasin, an Escherichia coli-cidal antimicrobial protein, has been found to be overexpressed in psoriasis, a skin disease characterized by infiltration of neutrophils.
|
18194266 |
2008 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Human psoriasin (S100A7), a member of the S100 family of calcium-binding proteins, is richly expressed in keratinocytes of patients suffering from psoriasis.
|
16262268 |
2005 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Psoriasin (S100A7) is a member of the S100 gene family that is involved in psoriasis, which can be induced in cultured squamous epithelial cells.
|
15201992 |
2004 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We determined, by serial analysis of gene expression (SAGE) analysis of normal and DCIS (ductal carcinoma in situ) mammary epithelial cells, that psoriasin and several other genes implicated in psoriasis are aberrantly expressed in high-grade, comedo DCIS.
|
11782356 |
2002 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Assignment of psoriasin to human chromosomal band 1q21: coordinate overexpression of clustered genes in psoriasis.
|
8618016 |
1996 |
|
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
For example, S100A7 is upregulated in psoriatic skin, implicating a link with psoriasis, a chronic inflammatory dermatosis.
|
8526920 |
1995 |
|
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The linkage information presented should be of great value in association and linkage studies of diseases where psoriasin, or some of the several other very closely linked and functionally related genes, are seen as candidate genes, e.g. in psoriasis.
|
8530009 |
1995 |
|
Pustulosis of Palms and Soles
|
0.300 |
Biomarker
|
disease |
CTD_human |
Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation.
|
18194266 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Psoriasin, a member of the S100 multigenic family, which is aberrantly expressed in a variety of human tumors, is considered as an attractive molecular target for cancer treatment.
|
29956751 |
2018 |