|
Duodenal Ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of the cagA gene was significantly associated with duodenal ulcer (p<0.05).
|
25228509 |
2014 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histology revealed the presence of infection in 68% of cases of mild/chronic nonspecific gastritis with others belonging to the GU sequel. cagA gene carriage was observed in 104 (51%) cases or mostly from DU, GU and GC groups, of which 97 were Western type strains while 3 were East-Asian type strains that are rarely observed in South Asia. vacA allelic variant s1am1 was most commonly observed, followed by s1am2, and s1bm1, with direct correlation in diseased cases (gastritis, GU, DU and GC).
|
23493000 |
2013 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, our findings indicated that serum concentrations of IL-18 were influenced by CagA factor, irrespective of the VacA status, suggesting that high levels of IL-18 in CagA-positive subjects predisposes to susceptibility to DU.
|
23746337 |
2013 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TPMs and 3' region structures of the H. pylori CagA gene in the duodenal ulcer and gastric adenocarcinoma patients have no significant differences.
|
23464450 |
2012 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the expression of cagA mRNA was confirmed by RT-PCR for the representative strains from both DU and NUD/AV subjects indicating the active cagA promoter regions of these strains.
|
21195664 |
2011 |
|
Duodenal Ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This does not support the view that subtypes of the 3' region of cagA gene in H. pylori isolated from Iran correlate with the clinical outcomes of H. pylori, but colonization with cagA positive strains was significantly higher among duodenal ulcer than gastritis patients in Iran.
|
18612816 |
2009 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied 144 patients with non-cardia gastric cancer (NCGC)(41/50 with present or past H. pylori infection), 75 with duodenal ulcer (DU)(66 H. pylori infected) and 171 with gastritis (CG)(107 H. pylori infected). cagA gene was present in 24/28 NCGC, 45/59 DU and 56/107 CG.
|
18179773 |
2008 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the cagA gene sequence was completely identical between the gastric corpus and the antrum in all patients, the corpus gastritis was more prominent in patients with gastric cancer than those with duodenal ulcer.
|
16543737 |
2006 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
The vacA s1a genotype was detected in 66.7, 96.4, and 87.9% of isolates from patients with NUD, DU, and GC, respectively, and its presence was significantly associated with that of DU (p = .004), GC (p = .043), and cagA gene (p = .021).
|
17083380 |
2006 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined the diversity of vacA and cagA genes in 143 isolates obtained from patients with duodenal ulcer or chronic gastritis in East Asia (two different areas of Japan, Fukui and Okinawa, and also in Hangzhou, China) by polymerase chain reaction (PCR) and sequence analysis.
|
14734191 |
2004 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
CagA gene was positively associated with DU and GU (P<0.01, P<0.02), but not with NUD (P>0.05).
|
12854168 |
2003 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
In resume there was a strong association between the H. pylori cagA+ gene and DU.
|
14595461 |
2003 |
|
Duodenal Ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, in 8 (18%) of the cases, more than one subtype was present, and an association between patients with multiple subtypes and disease outcome was observed when compared to patients with isolated subtypes (P = 0.048). cagA was a marker of H. pylori strains for duodenal ulcer disease in our population, and in spite of the differences in the 3' region of the cagA gene, the Japanese methodology was able to detect the cagA status in most cases.
|
11158115 |
2001 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cagA gene was detected in 80% of patients with DU and in 52% of those with gastritis (P < 0.0001).
|
10499473 |
1999 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
The CagA protein of Helicobacter pylori is an immunogenic antigen of variable size and unknown function that has been associated with increased virulence as well as two mutually exclusive diseases, duodenal ulcer and gastric carcinoma.
|
9666002 |
1998 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cagA gene was detected in 100% of 16 Helicobacter pylori isolates from patients with gastric carcinoma versus 78% of 18 isolates from patients with duodenal ulcers (P = 0.344) and only 64% of 22 isolates from patients with gastritis only (P = 0.005) in Brazil.
|
9774617 |
1998 |
|
Duodenal Ulcer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomic DNA was amplified by PCR, using synthetic oligonucleotide primers to the cagA gene to determine the prevalence of the cagA gene in 60 H. pylori isolates obtained from well-documented duodenal ulcer or asymptomatic gastritis patients (30 each).
|
9398887 |
1996 |
|
Duodenal Ulcer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, the cagA gene was detected in H. pylori isolates from 26 (81.3%) of 32 patients with duodenal ulcers (DU), 17 (68.0%) of 25 patients with gastric ulcers, and 23 (59.0%) of 39 patients with nonulcer dyspepsia (NUD).
|
7650174 |
1995 |