|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously showed that the proinflammatory molecule S100A9 in TME exerts a tumor-promoting effect in colorectal carcinoma (CRC).
|
31620141 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Subsequent immunohistochemistry of six Zn-binding proteins-zinc-α2-glycoprotein (AZGP1), Lipocalin-1, Albumin, S100A7, S100A8 and S100A9-revealed that only AZGP1 expression significantly correlated to HPV-status (p < 0.001) and was also increased in tumor relative to normal tissue from HPV-positive OPSCC tumor samples.
|
31740720 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Recent studies have suggested that S100A9 expression plays an important role during tumor development, progression and metastasis in various cancers.
|
31577709 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Serum biomarkers identification by iTRAQ and verification by MRM: S100A8/S100A9 levels predict tumor-stroma involvement and prognosis in Glioblastoma.
|
30808902 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An Oncolytic Adenovirus Vector Expressing p14 FAST Protein Induces Widespread Syncytium Formation and Reduces Tumor Growth Rate <i>In Vivo</i>.
|
31193718 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There was a significant correlation between the presence of MMTV (identified by p14 immunohistochemistry) in human breast cancers and histological characteristics similar to MMTV positive mouse mammary tumors (<i>p</i> = 0.001).
|
29868468 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We observed in protein extracts from spleen that both S100A8/S100A9 heterodimers as well as S100A9 homodimers were formed, both after tumor and inflammatory challenge.
|
29679568 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The disease-related structural isoform of MIF (oxMIF) can be specifically and predominantly detected in the circulation of patients with inflammatory diseases and in tumor tissue, whereas the ubiquitously expressed isoform of MIF (redMIF) is abundantly expressed in healthy and diseased subjects.
|
29412660 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
S100A8 and S100A9 positive expression in cancer tissues was significantly higher than in para-cancer tissues and was correlated with tumor differentiation, which may be a potential marker for poor prognosis.
|
29733516 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The calprotectin complex consisting of S100A8 and S100A9 proteins has recently been identified as key driver of chronic and tumor promoting inflammation in skin carcinogenesis.
|
29563902 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mechanically, the results of RNA-sequencing, in vitro coculture system and hypoxia measurements demonstrated that knockdown of CCL5 could result in the metabolic disorders in CD11b<sup>hi</sup>F4/80<sup>low</sup> TAMs and suppress the expression of S100a9 to promote the migration of CD8<sup>+</sup> T cells in the tumor microenvironment.
|
29991744 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results provide new insight and useful information to explain the possible mechanism(s) underlying the role of calgranulin B as an anti-tumor effector in colon cancer cells.
|
28036279 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, our aim was to determine the levels of S100A8 and S100A9 in the sera, and calprotectin levels in the sera and urines of bladder cancer patients and compare it to urinary BTA, a tumor marker that can be used in the diagnosis of bladder cancer.
|
28609200 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Calgranulin B is known to be involved in tumor development, but the underlying molecular mechanism is not clear.
|
28152021 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, colon tissue from GTN-treated mice had significantly less expression of the inflammatory genes interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), S100A9, interleukin 23A (IL-23A), IL-22 and IL-17A In the azoxymethane/DSS model of CAC, GTN reduced tumor multiplicity, load and size.
|
27797827 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MDSCs, immunosuppressive cells that contribute to tumor immune escape, are the main producers of S100A9.
|
28903971 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, the polyadenylated polycistronic transcripts containing full-size E1ORF and produced from the early P14 promoter were detected for the first time in cervical tumors with episomal forms of the HPV16 genome.
|
26655237 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The knockdown of S100A9 induced by RNA interference (RNAi) method in three osteosarcoma cell lines (U2OS, 143B, MG63) was applied to analyze the effects of S100A9 on cell proliferation, cell cycle distribution, migration, invasion and xenotransplanted tumors.
|
27020242 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Downregulation of S100A8 and S100A9 had no effect on subcutaneous tumor growth.
|
27086923 |
2016 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors.
|
26351750 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
S100A9-mediated release of IL-6 requires the crosstalk of tumor cells with monocytes through the activation of NF-κB and STAT-3.
|
26315114 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
S100a9(-/-) Mdr2(-/-) (dKO) mice displayed no significant differences in tumor incidence or multiplicity compared to Mdr2(-/-) animals.
|
25331529 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our findings indicate p14 (ARF) variants may predict tumor HPV16-positive SCCOP patients and survival.
|
24104554 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This resulted in underexpression of the tumor suppressor p14 alternate reading frame (p14ARF); the reduced DNA repair was corrected by transfection with p14ARF.
|
23661601 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Subsequent in vitro study in SiHa and C-33A human cervical squamous carcinoma cell lines revealed that knocking down galectin-7 or S100A9 enhanced tumor cell invasion and tumor cell viability against paclitaxel-induced apoptotic stress, likely through increasing the matrix metalloproteinase-9 expression and activating the phosphatidylinositol 3-kinase/Akt signaling pathway, respectively.
|
22864818 |
2013 |